134234-12-1

Basic information

• Product Name: (1S,2S)-1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDINO)-1-PROPANOL
• Synonyms: 1-((1S,2S);-1-Hydroxy-1-(4-hydroxyphenyl);propan-2-yl);(1S,2S)-1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDINO)-1-PROPANOL;CP 101606;1-[(1S,2S)-2-Hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]-4-phenylpiperidin-4-ol;(1s,2s)-1-[4-[ hydroxylphenyl]- 2- ( 4-hydroxy-4-pheny1piperidino)-1- propanol;1-((1S,2S)-1-Hydroxy-1-(4-hydroxyphenyl)propan-2-yl)-4-phenylpiperidin-4-ol
• CAS NO: 134234-12-1
• Molecular Formula: C20H25NO3
• Molecular Weight: 327.43
• Mol File: 134234-12-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 534.4°Cat760mmHg
• Flash Point: 290.3°C
• Appearance: white to tan/
• Density: 1.228
• Vapor Pressure: 2.98E-12mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: 2-8°C
• Solubility: DMSO: ≥35mg/mL
• PKA: 9.99±0.26(Predicted)
• CAS DataBase Reference: (1S,2S)-1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDINO)-1-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S)-1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDINO)-1-PROPANOL(134234-12-1)
• EPA Substance Registry System: (1S,2S)-1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDINO)-1-PROPANOL(134234-12-1)

Safety Data

• Hazard Codes: T,N
• Statements: 25-36-50
• Safety Statements: 26-45-61
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 134234-12-1(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 134234-12-1 differently. You can refer to the following data:
1. Traxoprodil (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC50 of 10 nM.
2. CP-101,606 has been used as a N-methyl-D-aspartate (NMDA)?receptor antagonist to study its role in recovery of spinal cord injuries.

Brand name

Traxoprodil is INN.

General Description

CP-101,606 (Traxoprodil) is a substituted 4-phenylpiperidine and is localized in the fore brain neurons.

Biochem/physiol Actions

Traxoprodil (CP-101,606) is a potent noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, selective for the NR2B subunit. It has been shown to be neuroprotective in animal models of brain injury and stroke.

InChI:InChI=1/C20H25NO3/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17/h2-10,15,19,22-24H,11-14H2,1H3/t15-,19+/m0/s1

Upstream product

• 70-70-2 4-hydroxypropiophenone 
• 169332-15-4 1-<4-<(triisopropylsilyl)oxy>phenyl>-2-(4-hydroxy-4-phenylpiperidino)-1-propanone 
• 134136-66-6 4-(triisopropylsilyloxy)-alpha-bromopropiophenone 
• 134136-88-2 1-(4-{[tris(1-methylethyl)silyl]oxy}phenyl)propan-1-one 
• 40807-61-2 4-hydroxy-4-phenylpiperidin 

Relevant articles and documents

Method for preventing dyskinesias

Dyskinesias in humans are prevented by administering a therapeutically effective dose of a NR1A/2B site-selective NMDA receptor antagonist compound to a human.

Prophylactic use of N-methyl-D-aspartate (NMDA) antagonists

This invention provides a method of inhibiting in a mammal neurological damage resulting from impairment of glucose and/or oxygen supply to the brain, which method comprises administering to the mammal prior to the impairment of glucose and/or oxygen supp

Method for treating diseased-related or drug-induced dyskinesias

Dyskinesias in humans are treated by administering a therapeutically effective dose of an NR1A/2B site-selective NMDA receptor antagonist compound to a human suffering therefrom.