134245-05-9Relevant academic research and scientific papers
Conformational restrictions of peptides via backbone modification: solution and crystal-state analysis of Boc-L-Pro-ΔZ-Phe-Gly-NH2
Piazzesi, Anna Maria,Bardi, Renato,Crisma, Marco,Bonora, Gian Maria,Toniolo, Claudio,et.al.
, p. 1 - 7 (2007/10/02)
An Nα-protected model tripeptide amide containing, in the central position an α,β-dehydrophenyladanine (Z-configurational isomer), Boc-L-Pro-ΔZ-Phe-Gly-NH2 (Boc, tert-butyloxycarbonyl), has been synthesized by solution methods and fully characterized.IR absorption and 1H NMR studies provided evidence for the occurence of a significant population of a conformer containing two consecutive, intramolecularly H-bonded (type II-III') β-bends in solution.However, an X-ray diffraction analysis clearly indicates that only the type-II β-bend structure survives in the crystal state
