134249-16-4Relevant academic research and scientific papers
Reduction of olefins using ruthenium carbene catalysts and silanes
Menozzi, Candice,Dalko, Peter I.,Cossy, Janine
, p. 2449 - 2452 (2007/10/03)
Ruthenium carbene complexes are able to mediate reduction of olefins in the presence of trialkylsilanes. Under these reduction conditions, when kinetically favorable ring-closing metathesis is possible, a one-pot cyclization-reduction sequence can be performed. Georg Thieme Verlag Stuttgart.
Solvent-modulated Pd/C-catalyzed deprotection of silyl ethers and chemoselective hydrogenation
Ikawa, Takashi,Hattori, Kazuyuki,Sajiki, Hironao,Hirota, Kosaku
, p. 6901 - 6911 (2007/10/03)
Recently we have reported undesirable and frequent deprotection of the TBDMS protective group of a variety of hydroxyl functions occurred under neutral and mild hydrogenation conditions using 10% Pd/C in MeOH. The deprotection of silyl ethers is susceptible to significant solvent effect. TBDMS and TES protecting groups were selectively cleaved in the presence of acid-sensitive functional groups such as TIPS ether, TBDPS ether and dimethyl acetal under hydrogenation condition using 10% Pd/C in MeOH. In contrast, chemoselective hydrogenation of reducible functional groups such as acetylene, olefin and benzyl ether, proceeds in the presence of TBDMS or TES ethers in AcOEt or MeCN.
