134255-98-4

Upstream product

• 129718-00-9 6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-one 
• 129718-05-4 C₁₉H₂₃ClN₂O₄ 
• 129718-06-5 6-cyano-3,4-dihydro-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,3-propylenedioxy-2H-1-benzopyran 
• 129718-03-2 C₁₅H₁₆N₄O₃ 
• 129718-01-0 C₁₅H₁₇NO₃ 
• 65018-90-8 3,4-epoxy-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile 
• 129717-99-3 6-cyano-3,4-dihydro-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-1-benzopyran-3-one 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

Structural Modifications of the Potassium Channel Activator Cromakalim: The C-3 Position

The syntheses of a selection of C-3 analogues of 6-cyano-3,4-dihydro-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-1-benzopyran-3-ol, the potassium channel activator cromakalim 1, are described.Particular interest has focused on the corresponding 3-ketone 2 and compounds in which the hydroxy group of 1 has been replaced by fluorine, carbon and nitrogen containing residues.The hindered neopentylic nature of the C-3 hydroxy group in 1 has a marked effect on its reactivity and has necessitated the independent synthesis of many of these analogues from simpler precursors rather than from the direct modification of compound 1 itself.