134271-75-3Relevant academic research and scientific papers
Structure-based design, synthesis and antiproliferative action of new quizoline-4-one/chalcone hybrids as EGFR inhibitors
Abdel-Aziz, Mohamed,Gomaa, Hesham A. M.,Hassan, Heba A.,Hayallah, Alaa M.,Hisham, Mohamed,Youssif, Bahaa G. M.
, (2022/01/24)
A new series of quinazoline-4-one/chalcone hybrids, 7–26, was synthesized in this study as EGFR inhibitors with antiproliferative activity. Target compounds were synthesized and in vitro tested against different cancer cell lines, EGFR, and BRAF enzymes.
