1342843-75-7Relevant academic research and scientific papers
One-Pot Synthesis of Functionalized Pyrimido[2,1-B][1,3]Thiazin-6-Ones Via a Multicomponent Reaction
Yadollahzadeh, Khadijeh,Azizian, Javad,Sanaeishoar, Haleh
, p. 2023 - 2030 (2015)
A facile and direct synthesis of pyrimido[2,1-b][1,3]thiazin-6-ones via a one-pot, three-component reaction of dialkyl acetylenedicarboxylates with alkyl or aryl isocyanides and 2-thioxopyrimidin-4-ones in good overall yields.
An efficient one-pot synthesis of pyrimido[2,1-b][1,3]thiazine derivatives by reaction of activated acetylenes, thiouracils, and isocyanides
Baharfar, Robabeh,Baghbanian, Seyed Meysam,Vahdat, Seyed Mohammad
supporting information; experimental part, p. 6018 - 6020 (2011/11/28)
The reactive 1:1 zwitterionic intermediate, formed by the addition of isocyanides to dialkyl acetylenedicarboxylates, was trapped by thiouracils to yield a ketenimine intermediate, which cyclized and then rearranged to afford pyrimido[2,1-b][1,3]thiazines
