134286-95-6Relevant academic research and scientific papers
Preparation and Utility of Dianions from N-tert-Butylthiophene-2-sulfonamide
Graham, Samuel L.,Scholz, Thomas H.
, p. 4260 - 4263 (1991)
Metalation of N-tert-butylthiophene-2-sulfonamide with n-butyllithium occurs competitively at the 3- and 5-position of the thiophene ring.Equilibration of the initial mixture of carbanions or metalation with lithiumdiisopropylamide allows selective formation of the N,5-dilithiothiophenesulfonamide 7.This dianion is useful for the preparation of a number of 5-substituted thiophene-2-sulfonamides.
