1342891-82-0

Upstream product

• 13707-46-5 N-tosyl-4-nitrobenzaldimine 
• 685-87-0 Diethyl 2-bromomalonate 
• 555-16-8 4-nitrobenzaldehdye 
• 70-55-3 toluene-4-sulfonamide 

Downstream Products

• 3585-95-3 3-(4-nitro-phenyl)-2-phenyl-oxaziridine 
• 1342891-90-0 diethyl 3-(4-methoxyphenyl)-5-(4-nitrophenyl)-1-tosyl-1H-pyrrole-2,2(5H)-dicarboxylate 
• 1342892-04-9 2,2-diethyl 4-methyl 5-(4-nitrophenyl)-3-(p-tolyl)-1-tosyl-1H-pyrrole-2,2,4(5H)-tricarboxylate 
• 1342892-03-8 diethyl 3-(4-methoxyphenyl)-5-(4-nitrophenyl)-4-phenyl-1-tosyl-1H-pyrrole-2,2(5H)-dicarboxylate 

Relevant academic research and scientific papers

TfOH-catalyzed formal [3+2] cycloaddition of N-tosylaziridine dicarboxylates and nitriles: Synthesis of tetrafunctionalized 2-imidazolines

We developed an efficient method for synthesis of tetrafunctionalized 2-imidazolines using TfOH-catalyzed formal [3+2] cycloaddition of N-tosylaziridine dicarboxylates and nitriles. This is the first report of C–N bond cleavage of N-tosylaziridine dicarboxylates catalyzed by Br?nsted acid and the reaction worked well over wide scope of substrates in good to excellent yields under mild conditions. The method has the potential to be applied to pharmaceutical design and synthesis of tetrafunctionalized 2-imidazolines.

Construction of thiazines and oxathianes: Via [3 + 3] annulation of N -tosylaziridinedicarboxylates and oxiranes with 1,4-dithiane-2,5-diol: Application towards the synthesis of bioactive molecules

Lewis acid catalyzed [3 + 3] annulation of N-tosylaziridinedicarboxylates and oxiranes with in situ generated mercaptoaldehyde for the synthesis of functionalized thiazine and oxathiane derivatives has been developed. Additionally, this method facilitates the derivatization of thiazines by detosylation and Krapcho monodecarboxylation.

Lewis Acid Catalyzed Annulation of Donor-Acceptor Cyclopropane and N-Tosylaziridinedicarboxylate: One-Step Synthesis of Functionalized 2H-Furo[2,3-c]pyrroles

An efficient MgI2-catalyzed annulation between donor-acceptor cyclopropane and N-tosylaziridinedicarboxylate to access highly substituted 2H-furo[2,3-c]pyrrole bearing two rings and four stereocenters, including one quaternary carbon stereocent

Direct aza-darzens aziridination of N-tosylimines with 2-bromomalonates for the synthesis of highly functionalized donor-acceptor aziridines

An approach to highly functionalized donor-acceptor aziridines by the aziridination of N-tosylimines and 2-bromomalonates in the presence of sodium hydride under mild conditions has been developed. The high-yielding reaction has a relatively broad scope and can be easily scaled up to the gram level.