13429-83-9 Usage
Description
(1S)-(-)-Camphanic acid, a white to slightly beige crystalline powder, is a versatile organic compound known for its applications in the synthesis of various chemicals and pharmaceuticals. It is commonly used as a chiral auxiliary for the separation of racemates, which is crucial in the production of enantiomerically pure compounds.
Uses
Used in Pharmaceutical Industry:
(1S)-(-)-Camphanic acid is used as a chiral auxiliary for the separation of racemates, which is essential in the production of enantiomerically pure compounds. This application is particularly important in the development of single-enantiomer drugs, as the different enantiomers of a drug can have significantly different pharmacological effects.
Used in Chemical Synthesis:
(1S)-(-)-Camphanic acid is used in the preparation of (-)-(1S,4R)-camphanoyl chloride by reacting with thionyl chloride. (1S)-(-)-Camphanic acid is an important intermediate in the synthesis of various chemicals and pharmaceuticals, showcasing the versatility of (1S)-(-)-Camphanic acid in different chemical reactions.
Purification Methods
Dissolve it in CH2Cl2, dry (MgSO4), filter, evaporate and the residue is sublimed at 120o/0.5mm or 140o/1mm. [Gerlach Helv Chim Acta 61 2773 1978, Beilstein 18/8 V 101.]
Check Digit Verification of cas no
The CAS Registry Mumber 13429-83-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,4,2 and 9 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 13429-83:
(7*1)+(6*3)+(5*4)+(4*2)+(3*9)+(2*8)+(1*3)=99
99 % 10 = 9
So 13429-83-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H14O4/c1-8(2)9(3)4-5-10(8,6(11)12)14-7(9)13/h4-5H2,1-3H3,(H,11,12)/t9?,10-/m0/s1
13429-83-9Relevant articles and documents
182. The Preparation of Optically Pure 7-Oxabicyclohept-2-ene Derivatives. The CD Spectrum of (+)-(1R)-7-Oxabicyclohept-5-en-2-one
Vieira, Eric,Vogel, Pierre
, p. 1865 - 1871 (1983)
(-)-1-Camphanoyloxyacrylonitrile (=(-)-1-cyanovinyl camphanate; 1) obtained from the commercially available (-)-camphanoyl chloride and 2-oxopropiononitrile added to furan at 20 deg C in the presence of Cu(BF4)2*6H2O or ZnI2 and gave a mixture of 2-cyano-
METHOD FOR THE PREPARATION OF FUSED HETEROCYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF
-
, (2008/06/13)
Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
Preparation of (-)-(1S,4R)-Camphanoyl Chloride heptane-1-carbonyl Chloride, 4,7,7-Trimethyl-3-oxo, (1S)->
Kappes, Dag,Gerlach, Hans
, p. 581 - 587 (2007/10/02)
A convenient three step procedure for the preparation of (-)-(1S,4R)-camphanoyl chloride, starting from (+)-camphoric acid (A) via (-)-bromocamphoric anhydride (B) and (-)-camphanic acid (C) is described.