134296-40-5 Usage
Uses
BIMU 8 is a potent full agonist of SR-4.
Biological Activity
bimu 8 is an agonist of 5-ht4 with ki values of 33.9 ± 8.0 nm and 12.6 ± 0.9 nm in guinea pig ileum and striatum, respectively [1, 2].as a member of the seven transmembrane spanning g-protein-coupled family of receptors, the 5-ht4 receptor is positively coupled to adenylate cyclase. it exists in two isoforms (5-ht4s and 5-ht4l). these two isoforms differ in the sequence and length of their carboxy termini [3].bimu 8 significantly decreased the k+ current in colliculi neurons. this suggested a 5-ht4 receptor-mediated effect [4]. in neurons, bimu 8 at concentrations ranging from 0.003-0.1 μm increased epsp amplitude but did not change membrane potential. the epsp potentiation induced by bimu 8 was blocked by tropisetron (1 μm), a 5-ht3/5-ht4 receptor antagonist. but ondansetron (1 μm), a 5-ht3 receptor antagonist did not blocked the epsp potentiation induced by bimu 8 [5].in the hot-plate test, bimu 8 injected i.p. in the range of doses of 20-30 mg/kg significantly induced an increase in the pain threshold. 15 min after administration, the antinociceptive effect reached a maximum and hence diminished. this effect disappeared within 45 min. choline uptake blocker hc-3 (1 μg per mouse i.c.v.), antimuscarinic drug atropine (5 mg/kg i.p.), 5-ht4 antagonists sdz 205-557 (10 mg/kg i.p.) and gr 125487 (20 mg/kg i.p.) completely prevented the antinociception of bimu 8 [1].
references
[1]. ghelardini c, galeotti n, casamenti f, et al. central cholinergic antinociception induced by 5ht4 agonists: bimu 1 and bimu 8. life sciences, 1996, 58(25): 2297-2309.[2]. yoshikawa t, yoshida n, mine y, et al. affinity of mosapride citrate, a new gastroprokinetic agent, for 5-ht4 receptors in guinea pig ileum. the japanese journal of pharmacology, 1998, 77(1): 53-59.[3]. hegde ss, eglen rm. peripheral 5-ht4 receptors. the faseb journal, 1996, 10(12): 1398-1407.[4]. fagni l, dumuis a, sebben m, et al. the 5-ht4 receptor subtype inhibits k+ current in colliculi neurones via activation of a cyclic amp-dependent protein kinase. british journal of pharmacology, 1992, 105(4): 973-979.[5]. pan h, galligan jj. 5-ht1a and 5-ht4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons. american journal of physiology-gastrointestinal and liver physiology, 1994, 266(2): g230-g238.
Check Digit Verification of cas no
The CAS Registry Mumber 134296-40-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,2,9 and 6 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 134296-40:
(8*1)+(7*3)+(6*4)+(5*2)+(4*9)+(3*6)+(2*4)+(1*0)=125
125 % 10 = 5
So 134296-40-5 is a valid CAS Registry Number.
InChI:InChI=1/C19H26N4O2.ClH/c1-12(2)22-16-6-4-5-7-17(16)23(19(22)25)18(24)20-13-10-14-8-9-15(11-13)21(14)3;/h4-7,12-15H,8-11H2,1-3H3,(H,20,24);1H/t13?,14-,15+;
