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Usage

Uses

Used in Pharmaceutical Industry:
C₆H₃ClN₂O₂S is used as an intermediate in the synthesis of various pharmaceuticals for its versatile chemical properties and reactivity in organic reactions.
Used in Pesticide Industry:
C₆H₃ClN₂O₂S is used as a key component in the formulation of pesticides, contributing to their effectiveness in controlling pests and protecting crops.
Used in Dye and Pigment Synthesis:
C₆H₃ClN₂O₂S is used as an intermediate in the synthesis of various dyes and pigments, providing a range of color options and enhancing the performance of these products in different applications.

Upstream product

• 501378-85-4 2-cyano-6-(2-phenethylthio)pyridine 
• 122918-25-6 6-bromopyridin-2-carbonitrile 

Downstream Products

• 39065-47-9 6-phenyl-pyridine-2-carbonitrile 

Relevant academic research and scientific papers

Desulfonative Suzuki–Miyaura Coupling of Sulfonyl Fluorides

Sulfonyl fluorides have emerged as powerful “click” electrophiles to access sulfonylated derivatives. Yet, they are relatively inert towards C?C bond forming transformations, notably under transition-metal catalysis. Here, we describe conditions under which aryl sulfonyl fluorides act as electrophiles for the Pd-catalyzed Suzuki–Miyaura cross-coupling. This desulfonative cross-coupling occurs selectively in the absence of base and, unusually, even in the presence of strong acids. Divergent one-step syntheses of two analogues of bioactive compounds showcase the expanded reactivity of sulfonyl fluorides to encompass both S?Nu and C?C bond formation. Mechanistic experiments and DFT calculations suggest oxidative addition occurs at the C?S bond followed by desulfonation to form a Pd-F intermediate that facilitates transmetalation.