134312-91-7Relevant academic research and scientific papers
Azaanalogues of ebselen as antimicrobial and antiviral agents: Synthesis and properties
Wojtowicz,Kloc,Maliszewska,Mlochowski,Pietka,Piasecki
, p. 863 - 868 (2004)
The different analogues of ebselen - unsubstituted benzisoselenazol-3(2H)- one (2a) 2-pyridylbenzisoselenazol-3(2H)-ones (2b-h) and 7-azabenzisoselenazol- 3(2H)-ones (3a-j) were designed as new selenium-containing antiviral and antimicrobial agents and synthesized. Some of them were found in the antiviral assay in vitro to be strong inhibitors of cythopatic activity of herpes simplex virus type 1 - HSV-1 (compounds 2a,b,f,h, 3a-j) and encephalomyocarditis virus - EMCV (compounds 2a,h, 3a-f,k,l). The compounds 2a,h and 3a-e,j were found to have an appreciable activity against Gram-positive bacteria (Staphylococcus aureus and Bacillus) in vitro, some of them inhibited growth of pathogenic yeasts (Candida albicans) (3a,b) and filamentous fungi (3a-e,f).
Synthesis of 7-Azabenzisoselenazol-3(2H)-ones: A New Group of Selenium Containing Antimicrobials
Kloc, Krystian,Maliszewska, Irena,Mlochowski, Jacek
, p. 3805 - 3815 (2003)
A convenient, general method for synthesis of various 2-substituted 7-azabenzisoselenazol-3(2H)-ones having pyridine ring condensed with selenazolone moiety is presented. It is based on the conversion of 2-chloronicotinic acid into 2-(chloroseleno)nicotin
Ortholithiation as a tool for the synthesis of Ebselen analogues
Lambert,Hilbert,Christiaens
, p. 85 - 98 (2007/10/02)
Ortholithiation reactions are shown to be effective tools for the synthesis of Ebselen (N-phenyl-benzisoselenazolin-3-one) derivatives.
