134330-11-3

Usage

Uses

Used in Pharmaceutical Synthesis:
2,4-Hexadienamide, N-(4-methylphenyl)-, (2E,4E)is used as a raw material in the synthesis of pharmaceuticals for its versatile chemical properties and reactivity in organic reactions.
Used in Agrochemical Production:
In the agrochemical industry, 2,4-Hexadienamide, N-(4-methylphenyl)-, (2E,4E)serves as a key intermediate in the production of various agrochemicals, contributing to the development of effective pest control agents.
Used in Rubber Chemicals Manufacturing:
2,4-Hexadienamide, N-(4-methylphenyl)-, (2E,4E)is utilized in the manufacturing of rubber chemicals, enhancing the performance and durability of rubber products.
Used in Polymer Resins and Coatings:
2,4-Hexadienamide, N-(4-methylphenyl)-, (2E,4E)is employed in the production of polymer resins and coatings, improving the properties of these materials and expanding their applications in various industries.
Used in Pharmaceutical Research:
2,4-Hexadienamide, N-(4-methylphenyl)-, (2E,4E)is used as a pharmaceutical intermediate in research, particularly for exploring its potential antitumor and anti-inflammatory properties, indicating its importance in the development of new therapeutic agents.

Upstream product

• 106-49-0 p-toluidine 
• 2614-88-2 sorbinyl chloride 
• 110-44-1 sorbic Acid 

Relevant academic research and scientific papers

Quantitative structure-activity relationship studies for prediction of antimicrobial activity of synthesized 2,4-hexadienoic acid derivatives

A new series of 2,4-hexadienoic acid derivatives (S1-S42) has been synthesized and evaluated as antimicrobial agents against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Candida albicans, and Aspergillus niger. Quantitative structure-activity relationship (QSAR) investigation using Hansch analysis was applied to find out correlation between antimicrobial activities with physicochemical properties of the synthesized compounds. Various physicochemical descriptors and experimentally determined minimum inhibitory concentration values for different microorganisms were used as independent and dependent variables, respectively. The QSAR revealed that topological parameters especially molecular connectivity indices (χ2, 0χv, 2χv) were found to have overall significant correlation with antimicrobial activity of 2,4-hexadienoic acid derivatives. The statistical results of training set, cross-validated r2 and conventional r values gave reliability to the prediction of molecules with activity using QSAR models.

Syntheses and QSAR studies of sorbic, cinnamic and ricinoleic acid derivatives as potential antibacterial agents

Amides and esters of sorbic, cinnamic and ricinoleic acid have been synthesized and evaluated for their antibacterial activity against gram (+) ve S. aureus, B. subtilis and gram (-) ve E. coli. Most of the compounds have shown moderate to good activity against microorganisms under test. Linear regression analysis of descriptors related to lipophilicity, steric and electronic parameters against antibacterial activity have been performed. QSAR studies indicated the predominance of electronic and steric parameters over the lipophilicity parameters in contributing antibacterial activity.

Synthesis of cyclopentaquinoline system

Reaction of N-aryl-sorbamides (3) with polyphosphoric acid gives cyclopentaquinolines (4) and 4-propyl-carbostyrils (5).