BCECF-AM, or 2',7'-Bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein acetoxymethyl ester, is a cell-permeable derivative of the pH-sensitive fluorescent dye BCECF (2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein). It is widely used as a pH indicator to measure intracellular pH levels in live cells. Upon entering the cell, BCECF-AM is hydrolyzed by intracellular esterases to release the non-fluorescent BCECF, which becomes fluorescent upon binding to intracellular pH-dependent ions. This property allows for the measurement of pH levels in different cellular compartments and experimental conditions.
134331-92-3
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Basic information
- Product Name: BCECF-AM
- Synonyms: BCECF-AM;2',7'-BIS-(CARBOXYETHYL)-5(6')-CARBOXYFLUORESCEIN ACETOXYMETHYL ESTER;2',7'-BIS-(2-CARBOXYETHYL)-5-(AND-6)-CARBOXYFLUORESCEIN, ACETOXYMETHYL ESTER;2,7-BIS(2-CARBOXYETHYL)-5,6-CARBOXYFLUORESCEIN;2',7'-BIS(2-CARBOXYETHYL)-5(6)-CARBOXYFLUORESCEIN ACETOXYMETHYL ESTER;3'-O-Acetyl-2',7'-bis(carboxyethyl)-4or5-carboxyfluoresceindiacetoxymethylester;SPIRO(ISOBENZOFURAN-1(3H),9'-(9H)XANTHENE)-2',7'-DIPROPANOIC ACID
- CAS NO:134331-92-3
- Molecular Formula: C42H40O21
- Molecular Weight: 880.75
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: -20°C
- Solubility: N/A
- CAS DataBase Reference: BCECF-AM(CAS DataBase Reference)
- NIST Chemistry Reference: BCECF-AM(134331-92-3)
- EPA Substance Registry System: BCECF-AM(134331-92-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: 24/25
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 134331-92-3(Hazardous Substances Data)
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134331-92-3 Usage
Uses
Used in Cellular Physiology Research:BCECF-AM is used as a pH indicator for studying intracellular pH regulation, ion channel function, and cell signaling processes in cellular physiology.
Used in Biomedical Research:
BCECF-AM is used as a tool for monitoring pH changes in various cellular processes, such as cell metabolism, cell death, and cell proliferation, in biomedical research.
Used in Drug Discovery and Development:
BCECF-AM is used as a screening tool to evaluate the effects of potential drugs on intracellular pH levels, which can provide insights into the mechanisms of action and potential therapeutic applications of these drugs.
Used in Environmental Toxicology:
BCECF-AM is used as a bioindicator to assess the impact of environmental toxins and pollutants on cellular pH homeostasis, which can help in understanding the mechanisms of toxicity and developing strategies for environmental protection and remediation.
Used in Agricultural Research:
BCECF-AM is used as a tool to study the effects of various agricultural chemicals, such as pesticides and fertilizers, on cellular pH levels in plant cells, which can provide insights into their impact on plant health and productivity.
Check Digit Verification of cas no
The CAS Registry Mumber 134331-92-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,3,3 and 1 respectively; the second part has 2 digits, 9 and 2 respectively.Calculate Digit Verification of CAS Registry Number 134331-92:
(8*1)+(7*3)+(6*4)+(5*3)+(4*3)+(3*1)+(2*9)+(1*2)=103
103 % 10 = 3
So 134331-92-3 is a valid CAS Registry Number.
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BCECF-AM
