134346-88-6

Basic information

• Product Name: 4-[(4-chlorobenzyl)amino]-4-oxobutanoic acid
• Synonyms: 4-[(4-chlorobenzyl)amino]-4-oxobutanoic acid
• CAS NO: 134346-88-6
• Molecular Formula: C₁₁H₁₂ClNO₃
• Molecular Weight: 241.68
• Mol File: 134346-88-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-[(4-chlorobenzyl)amino]-4-oxobutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(4-chlorobenzyl)amino]-4-oxobutanoic acid(134346-88-6)
• EPA Substance Registry System: 4-[(4-chlorobenzyl)amino]-4-oxobutanoic acid(134346-88-6)

Safety Data

• Hazardous Substances Data: 134346-88-6(Hazardous Substances Data)

Upstream product

• 108-30-5 succinic acid anhydride 
• 104-86-9 4-chlorobenzylamine 

Relevant articles and documents

Poststatin, a new inhibitor of prolyl endopeptidase. VII. N-cycloalkylamide analogues

Poststatin analogues containing (S)-2-oxo-2-(2-pyrrolidinyl)acetyl moiety in P1 were synthesized and examined for their inhibitory activity against prolyl endopeptidase and cathepsin B in vitro. Introduction of non-peptidyl cycloalkylamine component in P'1 was effective and P3-acyl groups must be widely modifiable for prolyl endopeptidase inhibition. Acyl-L-phenylalanyl-(S)-2-oxo-2-(2-pyrrolidinyl)acetyl-cycloalkylamide type compounds showed IC50 value of nano to subnano g/ml as prolyl endopeptidase inhibitor and were shown no significant inhibitory activities against cathepsin B, a cysteine protease.