N3-PEG8-CH2COOH, also known as Azido-PEG8-CH2CO2H, is an aqueous soluble PEG linker that features a hydrophilic PEG spacer, an azide (N3) group, and a terminal carboxylic acid. The hydrophilic PEG spacer enhances solubility in aqueous media, while the azide group enables reactions with alkyne, BCN, and DBCO through Click Chemistry, resulting in a stable triazole linkage. The terminal carboxylic acid allows for the formation of stable amide bonds with primary amine groups in the presence of activators such as EDC or HATU.
1343472-07-0
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Basic information
- Product Name: N3-PEG8-CH2COOH
- Synonyms: N3-PEG8-CH2COOH;Azido-PEG8-CH2CO2H
- CAS NO:1343472-07-0
- Molecular Formula: C18H35N3O10
- Molecular Weight: 453.49
- EINECS: -0
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: N3-PEG8-CH2COOH(CAS DataBase Reference)
- NIST Chemistry Reference: N3-PEG8-CH2COOH(1343472-07-0)
- EPA Substance Registry System: N3-PEG8-CH2COOH(1343472-07-0)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1343472-07-0(Hazardous Substances Data)
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1343472-07-0 Usage
Uses
Used in Bioconjugation:N3-PEG8-CH2COOH is used as a bioconjugation agent for the attachment of various biomolecules, such as proteins, peptides, and antibodies, to other molecules or surfaces. The azide group facilitates Click Chemistry reactions, enabling the formation of stable triazole linkages with alkyne-containing molecules.
Used in Drug Delivery Systems:
In the pharmaceutical industry, N3-PEG8-CH2COOH is used as a component in drug delivery systems to improve the solubility, stability, and targeted delivery of therapeutic agents. The hydrophilic PEG spacer and terminal carboxylic acid allow for the attachment of drug molecules and the formation of stable amide bonds with other components of the delivery system.
Used in Materials Science:
In materials science, N3-PEG8-CH2COOH is used as a building block for the development of functional materials with tailored properties. The azide group and terminal carboxylic acid enable the formation of stable linkages with other molecules, allowing for the creation of complex structures and materials with specific characteristics.
Used in Chemical Synthesis:
N3-PEG8-CH2COOH is used as an intermediate in the synthesis of various chemical compounds, taking advantage of its reactive azide group and terminal carboxylic acid. This allows for the incorporation of the PEG linker into a wide range of molecules, enhancing their properties and potential applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1343472-07-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,3,4,7 and 2 respectively; the second part has 2 digits, 0 and 7 respectively.Calculate Digit Verification of CAS Registry Number 1343472-07:
(9*1)+(8*3)+(7*4)+(6*3)+(5*4)+(4*7)+(3*2)+(2*0)+(1*7)=140
140 % 10 = 0
So 1343472-07-0 is a valid CAS Registry Number.
1343472-07-0Upstream product
1343472-07-0Downstream Products
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N3-PEG8-CH2COOH
