1343473-95-9

Upstream product

• 303-81-1 novobiocin 
• 3068-32-4 1-bromo-1-deoxy-2,3,4,6-tetra-O-acetyl-a-D-galactopyranoside 
• 83-87-4 penta-O-acetyl-α-D-galactopyranose 
• 10257-28-0 D-Galactose 
• 1476-53-5 sodium novobiocin 
• 1343473-92-6 β-4'-O-(2,3,4,6-tetra-acetyl galactosyl) novobiocin 

Relevant academic research and scientific papers

Regioselective glycosylation of novobiocin alters activity

Glycosylation is a promising approach to overcome antimicrobial drug resistance. In this study, we investigated Koenigs-Knorr and phase transfer glycosylation on novobiocin. While the former only gave a 4′-OH product, the later produced mainly a kinetic c

GLYCOSYLATED AMINOCOUMARINS AND METHODS OF PREPARING AND USES OF SAME

There is provided a method of glycosylating an aminocoumarin compound comprising conjugating a sugar to the 4′-OH position of the core of the aminocoumarin compound. Also provided is an aminocoumarin compound glycosylated at the 4′-OH position of the core of the aminocoumarin compound. Further aspects of this invention provide this compound for use in therapy, more particularly for use as an antibiotic, or in anticancer treatment.

GLYCOSYLATED AMINOCOUMARINS AND METHODS OF PREPARING AND USES OF SAME

There is provided a method of glycosylating an aminocoumarin compound comprising conjugating a sugar to the 4'-OH position of the core of the aminocoumarin compound. Also provided is an aminocoumarin compound glycosylated at the 4'-OH position of the core