Acid-PEG5-NHS ester is a PEG (polyethylene glycol) linker that features a carboxylic acid and an NHS (N-hydroxysuccinimide) ester. This molecule is designed to enhance solubility in aqueous environments due to the hydrophilic nature of the PEG spacer. The terminal carboxylic acid allows for the formation of stable amide bonds with primary amine groups, facilitated by the presence of activators such as EDC (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide) or HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide). Additionally, the NHS ester functionality enables the labeling of primary amines found in proteins, amine-modified oligonucleotides, and other molecules containing amine groups.
1343476-41-4
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Basic information
- Product Name: Acid-PEG5-NHS ester
- Synonyms: Acid-PEG5-NHS ester;COOH-PEG5-NHS
- CAS NO:1343476-41-4
- Molecular Formula: C18H29NO11
- Molecular Weight: 435.42296
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1343476-41-4.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 574.8±60.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.30±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 4.28±0.10(Predicted)
- CAS DataBase Reference: Acid-PEG5-NHS ester(CAS DataBase Reference)
- NIST Chemistry Reference: Acid-PEG5-NHS ester(1343476-41-4)
- EPA Substance Registry System: Acid-PEG5-NHS ester(1343476-41-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1343476-41-4(Hazardous Substances Data)
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1343476-41-4 Usage
Uses
Used in Bioconjugation:Acid-PEG5-NHS ester is used as a bioconjugation agent for the attachment of proteins, peptides, and other biomolecules to various surfaces or other molecules. The reason for this application is its ability to form stable amide bonds with primary amine groups, which facilitates the covalent linkage of these biomolecules.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Acid-PEG5-NHS ester is used as a component in drug delivery systems for the modification of drug molecules. The purpose of this application is to improve the solubility, stability, and bioavailability of drugs, as well as to enable targeted drug delivery.
Used in Diagnostics and Imaging:
Acid-PEG5-NHS ester is used as a labeling agent in diagnostics and imaging applications. The reason for this application is its ability to label amine-containing molecules, such as proteins or oligonucleotides, with various imaging agents or probes, allowing for their detection and tracking within biological systems.
Used in Research and Development:
In research settings, Acid-PEG5-NHS ester is used as a tool for the modification and functionalization of amine-containing molecules. This application is valuable for studying the properties and interactions of these molecules, as well as for developing new materials and technologies based on their modified properties.
Check Digit Verification of cas no
The CAS Registry Mumber 1343476-41-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,3,4,7 and 6 respectively; the second part has 2 digits, 4 and 1 respectively.Calculate Digit Verification of CAS Registry Number 1343476-41:
(9*1)+(8*3)+(7*4)+(6*3)+(5*4)+(4*7)+(3*6)+(2*4)+(1*1)=154
154 % 10 = 4
So 1343476-41-4 is a valid CAS Registry Number.
1343476-41-4Upstream product
1343476-41-4Downstream Products
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Acid-PEG5-NHS ester
