1343495-52-2Relevant academic research and scientific papers
Application of a double aza-Michael reaction in a click, click, cy-click strategy: From bench to flow
Zang, Qin,Javed, Salim,Ullah, Farman,Zhou, Aihua,Knudtson, Christopher A.,Bi, Danse,Basha, Fatima Z.,Organ, Michael G.,Hanson, Paul R.
experimental part, p. 2743 - 2750 (2011/10/09)
The development of a click, click, cy-click process utilizing a double aza-Michael reaction to generate functionalized 1,2,5-thiadiazepane 1,1-dioxides is reported. Optimization in flow, followed by scale out of the inter-/intramolecular double aza-Michael addition has also been realized using a microwave-assisted, continuous flow organic synthesis platform (MACOS). In addition, a facile one-pot, sequential strategy employing in situ Huisgen cycloaddition post-double aza-Michael has been accomplished, and is applicable to library synthesis. Georg Thieme Verlag Stuttgart - New York.
