13435-12-6 Usage
Chemical Properties
WHITE TO YELLOWISH CRYSTALLINE MASS
Uses
N-Trimethylsilylacetamide is a silylating agent used in organic synthesis. N-Trimethylsilylacetamide is used in the preparation of the antibacterial agent Cefdinir (C242670).
General Description
The efficiency of N-(Trimethylsilyl)acetamide (TMS acetamide) as allyl group scavenger and its compatibility with Fluorenylmethyloxycarbonyl chloride (Fmoc) protecting groups were studied.
Purification Methods
Distil the amide repeatedly in an inert atmosphere with all operations to be performed in an anhydrous atmosphere. In the presence of moisture, trimethylsilanol (b 31-34o/26mm) is formed and is a likely impurity (check by NMR). [Birkofer et al. Chem Ber 96 1473 1963, Beilstein 4 IV 4011.]
Check Digit Verification of cas no
The CAS Registry Mumber 13435-12-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,4,3 and 5 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 13435-12:
(7*1)+(6*3)+(5*4)+(4*3)+(3*5)+(2*1)+(1*2)=76
76 % 10 = 6
So 13435-12-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H13NOSi/c1-8(2,3)4-5(6)7/h4H2,1-3H3,(H2,6,7)
13435-12-6Relevant articles and documents
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Schirawskski,Wannagat
, p. 1901,1908 (1969)
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&α-L-ribo-Configured Locked Nucleic Acid (&α-L-LNA): Synthesis and Properties
Soerensen, Mads D.,Kvaernoe, Lisbet,Bryld, Torsten,Hakansson, Anders E.,Verbeure, Birgit,Gaubert, Gilles,Herdewijn, Piet,Wengel, Jesper
, p. 2164 - 2176 (2007/10/03)
The syntheses of monomeric nucleosides and 3'-O-phosphoramidite building blocks en route to α-L-ribo-configured locked nucleic acids (α-L-LNA), composed entirely of α-L-LNA monomers (α-L-ribo configuration) or of a mixture of α-L-LNA and DNA monomers (β-D
Synthesis of phosphino oxazoline ligand libraries from amino acid and phosphino carboxylate building blocks
Gilbertson, Scott R.,Chang, Cheng-Wei T.
, p. 8424 - 8431 (2007/10/03)
A modular route to new phosphine-oxazoline ligands is reported. The ability of these ligands to asymmetrically catalyze the addition of dimethyl malonate to 1,3-diphenylprop-2-enyl acetate was investigated. The best of these ligands gave a palladium complex which catalyzed the addition of dimethyl malonate to 1,3-diphenylprop-2-enyl acetate in a 99% yield and in 98% enantiomeric excess (Table 3, entry 11).
