134356-72-2

Upstream product

• 501-53-1 benzyl chloroformate 
• 134295-32-2 1-benzyloxycarbonyl-4-(4-fluorophenyl)hydroxymethyl-piperidine 
• 131417-40-8 1-benzyloxycarbonyl-4-(4-fluorobenzoyl)-piperidine 
• 56346-57-7 (4-fluorophenyl)-piperidin-4-ylmethanone 
• 134295-33-3 R-(+)-1-benzyloxycarbonyl-4-(4-fluorophenyl)acetoxymethyl-piperidine 

Downstream Products

• 134295-36-6 R-(+)-4-(4-fluorophenyl)hydroxymethyl-piperidine 
• 134295-41-3 2-(4-Fluoro-phenyl)-2-{4-[(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-ethanol 
• 134295-40-2 (-)-1-<(R)-2-(4-fluorophenyl)-2-hydroxyethyl>-4-<(R)-(4-fluorophenyl)hydroxymethyl>-piperidine 
• 134295-38-8 (+)-1-<(S)-2-(4-fluorophenyl)-2-hydroxyethyl>-4-<(R)-(4-fluorophenyl)hydroxymethyl>-piperidine 

Relevant academic research and scientific papers

Multigram lipase-catalyzed enantioselective acylation in the synthesis of the four stereoisomers of a new biologically active α-aryl-4-piperidinemethanol derivative

The four stereoisomers of the novel non-narcotic analgesic 1-[2-(4-fluorophenyl)-2-hydroxyethyl]-4-[(4-fluorophenyl)hydroxymethyl ]-piperidine 1 were synthesized in a convergent manner from chiral precursors 2 and 3. Optical resolution via enantioselective acylation in organic media, catalyzed by a lipase from Pseudomonas sp., was utilized in the preparation of 2 and 3 on a multigram scale with high enantiomeric purity (>97% ee).