134356-87-9

Upstream product

• 13081-18-0 ethyl-3,3,3-trifluoropyruvate 
• 621-84-1 O-benzyl carbamate 
• 59733-95-8 ethyl 3,3,3-trifluoromethyl-2-diazopropionate 
• 255379-07-8 ethyl (2E)-2-{[(benzyloxy)carbonyl]imino}-3,3,3-trifluoropropanoate 
• 1334313-60-8 (E)-ethyl 3,3,3-trifluoro-2-(2-tosylhydrazono)propanoate 
• 137174-48-2 Ethyl-3,3,3-trifluor-2-(formylamino)-2-hydroxypropanoat 
• 137174-49-3 Ethyl-2-chlor-3,3,3-trifluor-2-(formylamino)-propanoat 
• 137174-51-7 ethyl 2-isocyanato-3,3,3-trifluoropropionate 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1429777-53-6 2-{[(benzyloxy)carbonyl]amino}-3,3,3-trifluoropropyl methanesulfonate 
• 1429777-54-7 benzyl (3-azido-1,1,1-trifluoropropan-2-yl)carbamate 
• 276863-01-5 (2-hydroxy-1-trifluoromethylethyl)carbamic acid benzyl ester 

Relevant academic research and scientific papers

3-PYRIDYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (Syk) INHIBITORS

The invention provides certain 3-pyridyl carboxamide-containing compounds of the Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein A and B are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.

Rapid access to α-alkoxy and α-amino acid derivatives through safe continuous-flow generation of diazoesters

Microreactors: A highly efficient continuous-flow process has been developed for the synthesis of diazoesters from arylsulfonylhydrazones by means of in-flow Bamford-Stevens reactions. Furthermore, a range of α-alkoxy and α-amino acid derivatives have bee

CETP INHIBITORS

Compounds of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. I

Formylimine versus Isocyanate - an Unusual Tautomerism of a Trifluoroalanine Derivative

The intermediate 7a formed by hydrogen chloride elimination of 6 can easily tautomerize to the isolable isocyanate 7b.Depending on the reaction conditions nucleophiles react with 7a and 7b to give the corresponding products 8 or 9, respectively. Key Words

New Synthetic Pathways to 3,3,3-Trifluoroalanine, 2-Deutero-3,3,3-trifluoroalanine and their Derivatives

New synthetic pathways to 3,3,3-trifluoroalanine, 2-deutero-3,3,3-trifluoroalanine, their esters, amides, and thioamides are described, starting from hexafluoroacetone, and trifluoropyruvates, respectively.