13436-87-8

Basic information

• Product Name: N-(Hydroxymethyl)salicylamide
• Synonyms: N-(Hydroxymethyl)salicylamide;Benzamide, 2-hydroxy-N-(hydroxymethyl)- (9ci);Brn 2964257;Methylol salicylamide;Nsc 30181;Salicylamide, N-(hydroxymethyl)-;2-Hydroxy-N-hydroxymethyl-benzamide
• CAS NO: 13436-87-8
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.163
• Mol File: 13436-87-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 408.6°Cat760mmHg
• Flash Point: 200.9°C
• Appearance: /
• Density: 1.329g/cm³
• Vapor Pressure: 2.08E-07mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: N-(Hydroxymethyl)salicylamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(Hydroxymethyl)salicylamide(13436-87-8)
• EPA Substance Registry System: N-(Hydroxymethyl)salicylamide(13436-87-8)

Safety Data

• Hazardous Substances Data: 13436-87-8(Hazardous Substances Data)

Usage

General Description

N-(Hydroxymethyl)salicylamide, also known as salicylanilide, is an organic compound with the molecular formula C8H9NO3. It is a derivative of salicylic acid and contains a hydroxymethyl group. This chemical compound has been studied for its potential pharmaceutical and therapeutic applications, particularly as an anti-inflammatory and analgesic agent. It has also been used as a precursor for the synthesis of other organic compounds. Research on N-(Hydroxymethyl)salicylamide continues to explore its potential uses in medicine and other fields.

InChI:InChI=1/C8H9NO3/c10-5-9-8(12)6-3-1-2-4-7(6)11/h1-4,10-11H,5H2,(H,9,12)

Upstream product

• 50-00-0 formaldehyd 
• 65-45-2 salicylamide 

Downstream Products

• 19522-90-8 benzoylamino-salicyloylamino-methane 
• 19522-87-3 N,N'-methanediyl-bis-salicylamide 
• 1228166-94-6 C₄₁H₃₂N₂O₆ 
• 875557-21-4 2-Hydroxy-N-{3-[1-phenyl-meth-(E)-ylidene-hydrazinocarbonyl]-benzyl}-benzamide 
• 875557-15-6 N-(3-hydrazinocarbonyl-benzyl)-2-hydroxy-benzamide 
• 19522-79-3 3-[(2-Hydroxy-benzoylamino)-methyl]-benzoic acid 
• 19522-74-8 2-hydroxy-N-(1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-ylmethyl)-benzamide 
• 19522-72-6 N-(4-hydroxy-5-isopropyl-2-methyl-benzyl)-salicylamide 

Relevant articles and documents

Synthesis, characterization and biological activity of 1,3,4-substituted 2-azetidinones

Amido/imido alcohol/2-phenyl-3-hydroxyethylquinazolin-4 (3H) -one 1 on treatment with benzoic acid in the presence of cone. H2SO4 yields m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxoquinazolinyl) benzoic acids 2. The acid chloride of 2 on reaction with hydrazine hydrate affords m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo-quinazolinyl) benzoic acid hydrazides 4 which on condensation with an aromatic aldehyde in acetic acid gives m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo- quinazolinyl) benzoic acid hydrazones 5. Compounds 5 undergo cyclization with phenoxy acetic acid in the presence of thionyl chloride in dry benzene to furnish 1-[m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo-quinazolinyl- benzamido)]-3-phenoxy-4-phenyl-2-azetidinones 6. The antiviral and antifungal activities of 6 have been reported.