134362-79-1

Basic information

• Product Name: RO 0437626
• Synonyms: RO 0437626;N-[(1R)-2-[[(1S,2R,3S)-1-(Cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]amino]-2-oxo-1-(4-thiazolylmethyl)ethyl]-1H-benzimidazole-2-carboxamide
• CAS NO: 134362-79-1
• Molecular Formula: C27H35N5O4S
• Molecular Weight: 525.67
• Mol File: 134362-79-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Store at -20°C
• CAS DataBase Reference: RO 0437626(CAS DataBase Reference)
• NIST Chemistry Reference: RO 0437626(134362-79-1)
• EPA Substance Registry System: RO 0437626(134362-79-1)

Safety Data

• Hazardous Substances Data: 134362-79-1(Hazardous Substances Data)

Usage

Uses

Ro 0437626 is a P2X1 purinergic receptor antagonist.

Biological Activity

Selective P2X 1 purinergic receptor antagonist (IC 50 = 3 μ M) that displays > 30-fold selectivity over P2X 2 , P2X 3 and P2X 2/3 receptors (IC 50 > 100 μ M).

Upstream product

• 134362-77-9 2-(R)-amino-N-[(1-(S)-cyclohexylmethyl-3-cyclopropyl-2-(R),3-(S)-dihydroxypropyl)amino]-3-thiazol-4-yl-propionamide 
• 2849-93-6 2-benzimidazolecarboxylic acid 
• 167823-29-2 4-cyclohexyl-3-(S)-ethoxycarbonylamino-2-(R)-hydroxybutyric acid 
• 134362-80-4 [1-(R)-(1-(S)-cyclohexylmethyl-3-cyclopropyl-2-(R),3(S)-dihydroxy-propylcarbamoyl)-thiazol-4-yl-ethyl]-carbamic acid tert-butyl ester 
• 861807-51-4 (1-(S)-cyclohexylmethyl-3-cyclopropyl-2-(R)-hydroxy-3-oxo-propyl)carbamic acid ethyl ester 
• 134362-04-2 (1S,2R,3S)-3-amino-4-cyclohexyl-1-cyclopropyl-butane-1,2-diol 

Relevant articles and documents

Discovery and synthesis of a novel and selective drug-like P2X1 antagonist

Although there is extensive literature to indicate that many different types of P2 purinoceptors are present in the lower urinary tract, the physiological role of these receptors in micturition is still uncertain. In part, this uncertainty has been caused by a lack of P2 subtype selective ligands. In this paper we report the discovery, gram scale synthesis, and binding results for 1, the first potent, drug-like, selective P2X1 receptor antagonist described. Compound 1 was shown to be more than 30-fold selective over other purinergic receptor subtypes.