134386-14-4Relevant academic research and scientific papers
Convenient primary amidation of N-protected phenylglycine and dipeptides without racemization or epimerization
Noguchi, Takuya,Jung, Seunghee,Imai, Nobuyuki
, p. 394 - 396 (2014/01/06)
Primary amidation of N-protected phenylglycine and dipeptide proceeded easily to afford the corresponding amides in 57-95% yields with 99% ee and 81-99% de, respectively. The procedure is very easy to avoid racemization and epimerization of the products in the reactions by keeping exactly the reaction temperature at -15 C when the activation of carboxylic acids, followed by the reaction of the mixed carbonic carboxylic anhydride with NH4Cl.
