1344033-31-3Relevant academic research and scientific papers
Design and synthesis of a library of chemokine antagonists
Bhalay, Gurdip,Albrecht, Birgit,Akhlaq, Mohammed,Baettig, Urs,Beer, David,Brown, Zarin,Charlton, Steven,Dunstan, Andrew,Bradley, Michelle,Gedeck, Peter,Glen, Angela,Howea, Trevor,Keller, Thomas,Leighton-Davies, Juliet,Li, Alice,McCarthy, Clive,Mocquet, Cecile,Owen, Charles,Nicklin, Paul,Rosethorne, Elizabeth
, p. 6249 - 6252 (2011)
A library of chemokine antagonists has been synthesized using a combination of solid and solution-phase chemistry. Structures of known chemokine antagonists were used to produce a pharmacophore which served to guide monomer selection. Several combinations of monomers have resulted in providing novel chemokine antagonists which in some cases display dual chemokine receptor antagonism.
