134415-18-2

Basic information

• Product Name: 2-(2-phenylethynyl)-1-pyrrolidinecarboxaldehyde
• CAS NO: 134415-18-2
• Molecular Weight: 199.252
• Mol File: 134415-18-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-phenylethynyl)-1-pyrrolidinecarboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-phenylethynyl)-1-pyrrolidinecarboxaldehyde(134415-18-2)
• EPA Substance Registry System: 2-(2-phenylethynyl)-1-pyrrolidinecarboxaldehyde(134415-18-2)

Safety Data

• Hazardous Substances Data: 134415-18-2(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Molecular weight

197.23 g/mol

Usage

Production of pharmaceuticals, fragrances, and other organic synthesis processes

Function

Intermediate for the synthesis of various pharmaceuticals and biologically active compounds

Characteristics

Aromatic properties

Potential applications

Medicinal and cosmetic products

Upstream product

• 130753-33-2 2-(phenylsulphonyl)-1-pyrrolidinecarboxaldehyde 
• 536-74-3 phenylacetylene 
• 61020-06-2 2-methoxy-1-pyrrolidinecarboxaldehyde 

Relevant articles and documents

Substitution reactions of 2-phenylsulphonyl-piperidines and -pyrrolidines with carbon nucleophiles: Synthesis of the pyrrolidine alkaloids norruspoline and ruspolinone

Several 2-phenylsulphonyl-piperidines and -pyrrolidines were prepared from the corresponding N-acyl aminals by treatment with benzenesulphinic acid. On reaction with various carbon nucleophiles these sulphones gave good yields of substitution products. Typical nucleophiles used in these studies were organometallic reagents derived from Grignard reagents and zinc halide together with silyl enol ethers, silyl ketene acetals, allylsilanes and trimethylsilyl cyanide in the presence of a Lewis acid. These methods were employed in the synthesis of two natural product alkaloids; Norruspoline (38) and Ruspolinone (40).