1344153-78-1

Upstream product

• 287724-86-1 (3R,4R)-(-)-3-methyl-4-(trimethylsilylethynyl)oxetan-2-one 
• 2975-46-4 3-(trimethylsilyl)prop-2-yn-1-al 
• 1344153-67-8 (2R,3R)-3-((tert-butyldimethylsilyl)oxy)-N-methoxy-N,2-dimethyl-5-(trimethylsilyl)pent-4-ynamide 
• 1344153-62-3 (3R,4S,7R,E)-8-((2R,6S)-6-(2-((tert-butyldiphenylsilyl)oxy)ethyl)tetrahydro-2H-pyran-2-yl)-4,7-dimethyl-1-(trimethylsilyl)oct-5-en-1-yn-3-yl acetate 
• 1344153-77-0 (3R,4S,7R,E)-8-((2S,4S,6R)-6-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-4-iodotetrahydro-2H-pyran-2-yl)-4,7-dimethyl-1-(trimethylsilyl)oct-5-en-1-yn-3-yl acetate 
• 1344153-76-9 (3R,4S,7R,E)-8-((2S,4R,6R)-6-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-4-hydroxytetrahydro-2H-pyran-2-yl)-4,7-dimethyl-1-(trimethylsilyl)oct-5-en-1-yn-3-yl acetate 
• 1344153-75-8 (3R,4S,7R,E)-8-((2S,6R)-6-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-4-oxotetrahydro-2H-pyran-2-yl)-4,7-dimethyl-1-(trimethylsilyl)oct-5-en-1-yn-3-yl acetate 
• 1344153-55-4 (3R,6S,7R,E)-7-hydroxy-3,6-dimethyl-9-(trimethylsilyl)non-4-en-8-ynal 
• 1344153-70-3 (3R,6S,7R,E)-7-((tert-butyldimethylsilyl)oxy)-3,6-dimethyl-9-(trimethylsilyl)non-4-en-8-ynal 
• 1344153-69-0 (3R,6S,7R,E)-7-((tert-butyldimethylsilyl)oxy)-3,6-dimethyl-9-(trimethylsilyl)non-4-en-8-yn-1-ol 
• 1344153-57-6 (3R,6S,7R,E)-7-((tert-butyldimethylsilyl)oxy)-N,N,3,6-tetramethyl-9-(trimethylsilyl)non-4-en-8-ynamide 
• 1344153-56-5 (5R,6R,E)-6-((tert-butyldimethylsilyl)oxy)-5-methyl-8-(trimethylsilyl)oct-2-en-7-yn-4-one 

Downstream Products

• 1344153-79-2 (S)-(3R,4S,7R,E)-8-((2R,6S)-6-(2-((tert-butyldiphenylsilyl)oxy)ethyl)tetrahydro-2H-pyran-2-yl)-4,7-dimethyl-1-(trimethylsilyl)oct-5-en-1-yn-3-yl (S)-3-((tert-butyldimethylsilyl)oxy)-4-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)butanoate 

Relevant academic research and scientific papers

Enantioselective synthesis of (-)-exiguolide by iterative stereoselective dioxinone-directed prins cyclizations

Three become one: The title compound can be prepared in 26 steps by employing a unified Prins cyclization strategy to construct both tetrahydropyran rings (see scheme). The route combines two similar dioxinone fragments and one aldehyde component to gener