13443-57-7

Basic information

• Product Name: 3-O-methylascorbic acid
• Synonyms: 3-O-methylascorbic acid
• CAS NO: 13443-57-7
• Molecular Formula: C₇H₁₀O₆
• Molecular Weight: 190.15
• Mol File: 13443-57-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 120-122 °C
• Boiling Point: 569.3°Cat760mmHg
• Flash Point: 240.1°C
• Appearance: /
• Density: 1.55g/cm³
• Vapor Pressure: 2.48E-15mmHg at 25°C
• Refractive Index: 1.566
• PKA: 8.78±0.40(Predicted)
• CAS DataBase Reference: 3-O-methylascorbic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-O-methylascorbic acid(13443-57-7)
• EPA Substance Registry System: 3-O-methylascorbic acid(13443-57-7)

Safety Data

• Hazardous Substances Data: 13443-57-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H10O6/c1-12-6-4(10)7(11)13-5(6)3(9)2-8/h3,5,8-10H,2H2,1H3/t3-,5?/m0/s1

Upstream product

• 186581-53-3 diazomethane 
• 89-65-6 isoascorbic acid 
• 50-81-7 ascorbic acid 
• 67-56-1 methanol 
• 66-27-3 Methyl methanesulfonate 
• 58650-92-3 5,6-O-isopropylidene-3-O-methyl-L-ascorbic acid 

Downstream Products

• 74421-65-1 L-threonamide 
• 471-46-5 Oxalamide 

Relevant articles and documents

Synthesis of 3-O-alkylascorbic acids from l-ascorbic acid in a single step

An efficient single step synthesis of 3-O-alkylascorbic acids from ascorbic acid is described.

Synthesis and cytotoxic evaluation of novel 3-O and 2, 3-Di-O-alkyl derivatives of L-ascorbic acid

A series of protected and unprotected 3-O and 2, 3-di-O-alkyl derivatives ofL-ascorbic acid were synthesized and their cytotoxic activity against metastatic breast epithelial carcinoma (MCF-7) cell line was evaluated. Cytotoxic activity evaluation indicated that compounds show moderate cytotoxic effects on tested cell line. Some of the 2, 3-di-O-alkyl derivatives ofL-ascorbic acid exhibited potent inhibiting activity against MCF-7 cell line at micromolar concentrations. 2,3-di-O-4-chlorobenzyl-L-ascorbic acid exhibited 4 fold more cytotoxic activity (IC50 = 34.09 μΜ) against MCF-7 cell line thanL-ascorbic acid. 2, 3-di-O-alkyl derivatives exhibited more inhibition against MCF-7 cell line as compared to the 3-O-alkyl derivatives ofL-Ascorbic acid.