134430-54-9Relevant academic research and scientific papers
SELECTIVE MONO- AND DIFLUORINATION OF ENOLATES
Differding, Edmond,Rueegg, Gabriela M.,Lang, Robert W.
, p. 1779 - 1782 (1991)
The selective transformation of enolates into mono- and difluorinated carbonyl compounds can be performed in a one-pot procedure using N-F-sultam 1.The yields and the selectivity of the fluorination strongly depend on the counterion of the enolate and the acidity of the protons α to the carbonyl group.
FLUORINATED HETEROCYCLES: TARGETS IN THE SEARCH FOR BIOACTIVE COMPOUNDS AND TOOLS FOR THEIR PREPARATION
Differding, E.,Frick, W.,Lang, R. W.,Martin, P.,Schmit, C.,et al.
, p. 647 - 671 (2007/10/02)
To strategies for the preparation and use of fluorinated heterocycles are discussed: 1.)the building block approach being used mainly for the preparation of target heterocycles with fluorinated substituents, and 2.)the direct fluorination approach in which fluorinated heterocycles are used as tools for the preparation of bioactive compounds.Strategies presented in the building block approach include electrophilic reactions of building blocks derived from trifluoroacetic acid (1), as well as the use of building blocks obtained from trichlorotrifluoroethane (2) and chlorodifluoro acetic acid (3) through organometallic reactions.The preparation and use of N-fluoro sultams 62 and 66 are shown in the direct fluorination approach.Both strategies can be successfully used n the synthesis of bioactive compounds of pharmaceutical and agrochemical interest.
