1344330-71-7Relevant academic research and scientific papers
Photoinduced Remote Functionalization of Amides and Amines Using Electrophilic Nitrogen Radicals
Morcillo, Sara P.,Dauncey, Elizabeth M.,Kim, Ji Hye,Douglas, James J.,Sheikh, Nadeem S.,Leonori, Daniele
, p. 12945 - 12949 (2018)
The selective functionalization of C(sp3)?H bonds at distal positions to functional groups is a challenging task in synthetic chemistry. Reported here is a photoinduced radical cascade strategy for the divergent functionalization of amides and protected amines. The process is based on the oxidative generation of electrophilic amidyl radicals and their subsequent transposition by 1,5-H-atom transfer, resulting in remote fluorination, chlorination and, for the first time, thioetherification, cyanation, and alkynylation. The process is tolerant of most common functional groups and delivers useful building blocks that can be further elaborated. The utility of this strategy is demonstrated through the late-stage functionalization of amino acids and a dipeptide.
CLASS OF HDAC INHIBITORS EXPANDS THE RENAL PROGENITOR CELLS POPULATION AND IMPROVES THE RATE OF RECOVERY FROM ACUTE KIDNEY INJURY
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Page/Page column 60, (2012/08/28)
Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided.
