134439-24-0

Basic information

• Product Name: FMOC-3-(2-THIENYL)-DL-ALANINE
• Synonyms: FMOC-3-(2-THIENYL)-DL-ALANINE;FMOC-DL-2-(THIENYL)ALANINE;FMoc-3-(thien-2-yl)-DL-alanine
• CAS NO: 134439-24-0
• Molecular Formula: C22H19NO4S
• Molecular Weight: 393.46
• Mol File: 134439-24-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: FMOC-3-(2-THIENYL)-DL-ALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-3-(2-THIENYL)-DL-ALANINE(134439-24-0)
• EPA Substance Registry System: FMOC-3-(2-THIENYL)-DL-ALANINE(134439-24-0)

Safety Data

• Hazardous Substances Data: 134439-24-0(Hazardous Substances Data)

Usage

General Description

FMOC-3-(2-thienyl)-DL-alanine is a chemical compound that belongs to the class of amino acids, specifically the DL-alanine derivatives. It is known for its fluorescent properties, as the FMOC (9-fluorenylmethoxycarbonyl) group attached to the amino acid allows for detection and monitoring using UV-Vis spectroscopy. The compound's 2-thienyl group also adds aromatic and potentially electroactive properties. FMOC-3-(2-thienyl)-DL-alanine has potential applications in bioconjugation, peptide synthesis, and as a fluorescence probe in biochemical research. It is an important tool for studying and understanding the behavior and interactions of amino acids and peptides in biological systems.

Upstream product

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Relevant articles and documents

Preparation method of non-natural amino acid N-fluorenylmethoxycarbonyl-beta-(2-thienyl)-D-alanine

The invention discloses a preparation method of non-natural amino acid N-fluorenylmethoxycarbonyl-beta-(2-thienyl)-D-alanine, and mainly solves the technical problems that an original technology is complex in use, low in yield, high in cost, and the like. The preparation method comprises the steps of step I, carrying out chlorine acylation on 2-thiophene methanol through a chlorine acylating agent, so as to prepare 2-chloromethyl thiophene; step II, enabling 2-chloromethyl thiophene and diethyl acetamidomalonate to react through sodium ethoxide, so as to prepare 2-thienyl diethyl malonate; and step III, enabling 2-thienyl diethyl malonate subjected to alkaline saponification and L-acetyl transferase resolution to react with fmoc-groups, filtering an obtained L amino protection product, collecting a mother liquid, adding hydrochloric acid and a methyl alcohol solution for reflux reaction, monitoring the reaction process through NMR, adding fmoc-osu for reaction, tracking and monitoring the reaction process through TLC, and carrying out impurity extraction, acidification, and the like, to obtain the N-fluorenylmethoxycarbonyl-beta-(2-thienyl)-D-alanine.