134439-24-0 Usage
Uses
Used in Bioconjugation:
FMOC-3-(2-thienyl)-DL-alanine is used as a building block in bioconjugation for the synthesis of complex biomolecules. Its fluorescent properties facilitate the tracking and analysis of these biomolecules in biological systems.
Used in Peptide Synthesis:
In peptide synthesis, FMOC-3-(2-thienyl)-DL-alanine serves as a key component for creating novel peptide sequences. Its unique structure and properties can influence the overall characteristics of the synthesized peptides, such as stability, solubility, and biological activity.
Used as a Fluorescence Probe in Biochemical Research:
FMOC-3-(2-thienyl)-DL-alanine is utilized as a fluorescence probe in biochemical research to study the behavior and interactions of amino acids and peptides within biological systems. Its fluorescent properties enable researchers to monitor these interactions in real-time, providing valuable insights into the underlying mechanisms and processes.
Used in Pharmaceutical Development:
FMOC-3-(2-thienyl)-DL-alanine has potential applications in the development of new pharmaceuticals. Its unique structure and properties can be leveraged to design drugs with specific targeting, delivery, and therapeutic properties, contributing to the advancement of medicine and healthcare.
Used in Chemical Synthesis:
In the field of chemical synthesis, FMOC-3-(2-thienyl)-DL-alanine can be employed as a reagent or intermediate in the production of various chemical compounds. Its aromatic and potentially electroactive properties make it a valuable component in the synthesis of specialty chemicals and materials.
Used in Analytical Chemistry:
FMOC-3-(2-thienyl)-DL-alanine can be utilized in analytical chemistry as a reference compound or standard for the development and validation of analytical methods. Its fluorescent properties can be advantageous in techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS) for the accurate identification and quantification of related compounds.
Used in Material Science:
In material science, FMOC-3-(2-thienyl)-DL-alanine can be incorporated into the design and synthesis of novel materials with specific properties. Its aromatic and potentially electroactive characteristics can contribute to the development of advanced materials for various applications, such as sensors, catalysts, and electronic devices.
Overall, FMOC-3-(2-thienyl)-DL-alanine is a versatile and valuable compound with a wide range of applications across different scientific disciplines and industries. Its unique structure and properties make it an essential tool for research, development, and innovation in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 134439-24-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,4,3 and 9 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 134439-24:
(8*1)+(7*3)+(6*4)+(5*4)+(4*3)+(3*9)+(2*2)+(1*4)=120
120 % 10 = 0
So 134439-24-0 is a valid CAS Registry Number.
134439-24-0Relevant articles and documents
Preparation method of non-natural amino acid N-fluorenylmethoxycarbonyl-beta-(2-thienyl)-D-alanine
-
Paragraph 0016-0018; 0021-0023; 0026-0027; 0030-0031; 0038, (2017/05/13)
The invention discloses a preparation method of non-natural amino acid N-fluorenylmethoxycarbonyl-beta-(2-thienyl)-D-alanine, and mainly solves the technical problems that an original technology is complex in use, low in yield, high in cost, and the like. The preparation method comprises the steps of step I, carrying out chlorine acylation on 2-thiophene methanol through a chlorine acylating agent, so as to prepare 2-chloromethyl thiophene; step II, enabling 2-chloromethyl thiophene and diethyl acetamidomalonate to react through sodium ethoxide, so as to prepare 2-thienyl diethyl malonate; and step III, enabling 2-thienyl diethyl malonate subjected to alkaline saponification and L-acetyl transferase resolution to react with fmoc-groups, filtering an obtained L amino protection product, collecting a mother liquid, adding hydrochloric acid and a methyl alcohol solution for reflux reaction, monitoring the reaction process through NMR, adding fmoc-osu for reaction, tracking and monitoring the reaction process through TLC, and carrying out impurity extraction, acidification, and the like, to obtain the N-fluorenylmethoxycarbonyl-beta-(2-thienyl)-D-alanine.
Novel selective inhibitors of the interaction of individual nuclear hormone receptors with a mutually shared steroid receptor coactivator 2
Geistlinger, Timothy R.,Guy, R. Kiplin
, p. 6852 - 6853 (2007/10/03)
Nuclear hormone receptor (NR) signaling, currently a therapeutic target in multiple diseases, involves an ordered series of protein interactions to regulate transcription in response to changing hormone levels. Later steps in the process of ligand-dependent signaling are driven by a highly conserved interaction between the NRs and the steroid receptor coactivators (SRCs) that is effected by a conserved interaction motif (L1XXL2L3), known as an NR box. Using computational design and combinatorial chemistry, we have produced novel ∞-helical proteomimetics of the second NR box of SRC2 that exploit structural differences between human estrogen receptor ∞ (hER∞), human estrogen receptor β (hERβ), and human thyroid hormone receptor β (hTRβ). The resulting library sequentially replaced each leucine with non-natural side chains. Screening this library using a quantitative competition assay revealed compounds that selectively inhibit the interaction of SRC2-2 with each individual NR in preference to its interaction with the other NR. This approach generated highly selective compounds from one that had no specificity for a particular family member. These compounds represent the first family-member-selective competitive inhibitors of the protein interactions of transcription factors. Copyright
