134457-28-6

Basic information

• Product Name: PRAZARELIX
• Synonyms: PRAZARELIX;Prazarelix [inn]
• CAS NO: 134457-28-6
• Molecular Formula: C₈₀H₁₀₂ClN₂₃O₁₂
• Molecular Weight: 1613.29
• Mol File: 134457-28-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.348g/cm³
• Refractive Index: 1.647
• CAS DataBase Reference: PRAZARELIX(CAS DataBase Reference)
• NIST Chemistry Reference: PRAZARELIX(134457-28-6)
• EPA Substance Registry System: PRAZARELIX(134457-28-6)

Safety Data

• Hazardous Substances Data: 134457-28-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C80H102ClN23O12/c1-44(2)35-59(68(108)91-58(16-9-10-33-86-45(3)4)76(116)104-34-12-17-66(104)75(115)87-46(5)67(82)107)92-70(110)62(38-49-21-28-56(29-22-49)89-79-98-77(83)100-102-79)94-72(112)63(39-50-23-30-57(31-24-50)90-80-99-78(84)101-103-80)96-74(114)65(43-105)97-73(113)64(41-52-13-11-32-85-42-52)95-71(111)61(37-48-19-26-55(81)27-20-48)93-69(109)60(88-47(6)106)40-51-18-25-53-14-7-8-15-54(53)36-51/h7-8,11,13-15,18-32,36,42,44-46,58-66,86,105H,9-10,12,16-17,33-35,37-41,43H2,1-6H3,(H2,82,107)(H,87,115)(H,88,106)(H,91,108)(H,92,110)(H,93,109)(H,94,112)(H,95,111)(H,96,114)(H,97,113)(H4,83,89,98,100,102)(H4,84,90,99,101,103)/t46-,58+,59+,60-,61-,62-,63+,64-,65+,66+/m1/s1

Upstream product

• 108-24-7 acetic anhydride 
• 98266-33-2 Boc-DPal 
• 57292-44-1 N-Boc-D-(4-Cl)Phe-OH 
• 76985-10-9 Boc-D-2Nal-OH 
• 114346-31-5 (R)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid 
• 79463-77-7 N-cyanodiphenylcarbonimidate 

Relevant articles and documents

Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized derivatives

A series of acyline analogues incorporating L- and D-isomers of S-arylated/alkylated norcysteines [Ncy(R), where R is 2-naphthyl, methyl, and isopropyl] at positions 1, 4, 7, and 10 were synthesized. Some of these analogues were mono- and dioxidized to sulfoxides and sulfones. All of the analogues of acyline were screened for the antagonism of the GnRH-induced response in a reporter gene assay in HEK-293 cells expressing the human GnRH receptor. Nine of the analogues (9, 11, 15, 16, 17, 19, 20, 21, and 22) had antagonistic potency (IC50 50 = 0.52 nM) in this assay. Selected analogues (9, 11, 15, 16, 19, and 21) were tested in vitro for their antagonism at the rat GnRH-R in a reporter gene assay as well as in an in vivo intact male rat assay. Analogues 9 and 15 were the most potent in suppressing testosterone levels.