1344663-93-9Relevant articles and documents
Facile one-pot direct arylation and alkylation of nitropyridine N -oxides with grignard reagents
Zhang, Fang,Duan, Xin-Fang
supporting information; experimental part, p. 6102 - 6105 (2012/01/06)
Facile arylation and alkylation of nitropyridine N-oxides were developed through the reactions of Grignard reagents with nitropyridine N-oxides. For the same 4-nitropyridine N-oxide, arylation occurred at the 2- (or 6-) position, whereas alkylation occurred at the 3-position in an adjustably site-selective manner. The cooperative action of the two groups was discovered in the reactions of 3-nitropyridine N-oxides. This protocol can find wide applications in building various pyridine compounds as illustrated in total syntheses of Emoxipin and Caerulomycin A and E.