1344673-90-0

Upstream product

• 1344673-87-5 (1S,2S)-2-(tert-butyldimethylsilyl)oxymethylcyclopent-3-en-1-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 1344673-74-0 2-[(2R,4S,5S,6R,7R)-7-[(E)-((2S,3S)-2-tert-butyldimethylsilyloxymethyl-3-tert-butyldiphenylsilyloxy-5-oxocyclopentylidene)methyl]-2-tert-butyldiphenylsilyloxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-6-yl]ethyl 2,2-dimethylpropanoate 
• 1344673-78-4 2-[(2R,4S,5S,6R,7R)-7-[((1S,2S,3S)-2-tert-butyldimethylsilyloxymethyl-3-tert-butyldiphenylsilyloxy-5-oxocyclopentyl)methyl]-2-tert-butyldiphenylsilyloxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-6-yl]ethyl 2,2-dimethylpropanoate 
• 1344673-92-2 (1R,2S,3S,4S)-3-tert-butyldimethylsilyloxymethyl-4-tert-butyldiphenylsilyloxy-2-{[(2R,4S,5S,6R,7R)-2-tert-butyldiphenylsilyloxymethyl-6-(2-hydroxyethyl)-4,7-dimethyl-1-oxaspiro[4.4]non-7-yl]methyl}-1-methylcyclopentanol 
• 1344673-93-3 [(2R,4S,5S,6R,7R)-7-[((1S,2R,4S,5S)-5-tert-butyldimethylsilyloxymethyl-4-tert-butyldiphenylsilyloxy-2-hydroxy-2-methylcyclopentyl)methyl]-2-tert-butyldiphenylsilyloxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-6-yl]acetaldehyde 
• 1344673-94-4 (1R,2S,3S,4S)-2-{[(2R,4S,5S,6R,7R)-6-allyl-2-tert-butyldiphenylsilyloxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-7-yl]methyl}-3-tert-butyldimethylsilyloxymethyl-4-tert-butyldiphenylsilyloxy-1-methylcyclopentanol 
• 1344673-79-5 (1R,2S,3S,4S)-2-{[(2R,4S,5S,6R,7R)-6-allyl-2-tert-butyldiphenylsilyloxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-7-yl]methyl}-4-tert-butyldiphenylsilyloxy-3-hydroxymethyl-1-methylcyclopentanol 
• 1344673-95-5 1-((1R,2S,3R,5S)-2-{[(2R,4S,5S,6R,7R)-6-allyl-2-tert-butyldiphenylsilyloxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-7-yl]methyl}-5-tert-butyldiphenylsilyloxy-3-hydroxy-3-methylcyclopentyl)ethanone 
• 1344673-80-8 1-{(1R,2S,3R,5S)-2-{[(2R,4S,5S,6R,7R)-6-allyl-2-tert-butyldiphenylsilyloxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-7-yl]methyl}-5-tert-butyldiphenylsilyloxy-3-methyl-3-trimethylsilyloxycyclopentyl}ethanone 
• 1344673-81-9 2-{(1S,2S,3R,5S)-2-{[(2R,4S,5S,6R,7R)-6-allyl-2-({[tert-butyl(diphenyl)silyl]oxy}methyl)-4,7-dimethyl-1-oxaspiro[4.4]non-7-yl]methyl}-5-{[tert-butyl(diphenyl)silyl]oxy}-3-methyl-3-[(trimethylsilyl)oxy]cyclopentyl}prop-2-en-1-ol 
• 1344673-73-9 (1R,2S,3S,4S)-4-(benzyloxy)-2-{[(2R,4S,5S,6R,7R)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4,7-dimethyl-6-prop-2-en-1-yl-1-oxaspiro[4.4]non-7-yl]methyl}-3-[1-(hydroxymethyl)ethenyl]-1-methylcyclopentanol 
• 4611-05-6 Ophiobolin A 
• 1344673-77-3 2-[(2R,4S,5S,6R,7S)-7-[(R)-((1S,2S,3S)-2-tert-butyldimethylsilyloxymethyl-3-tert-butyldiphenylsilyloxy-5-oxocyclopentyl)(hydroxy)methyl]-2-tert-butyldiphenylsilyloxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-6-yl]ethyl 2,2-dimethylpropanoate 

Relevant academic research and scientific papers

Convergent total synthesis of (+)-ophiobolin A

At long last: The enantioselective total synthesis of the title compound, which was isolated in 1958, proceeds by a convergent approach. The assembly of the C,D-ring fragment and the A-ring fragment of the core structure is achieved by employing a Reforma