1344682-04-7

Basic information

• Product Name: diisopropyl (2-oxo-2-(o-tolyl)ethyl)phosphonate
• Synonyms: diisopropyl (2-oxo-2-(o-tolyl)ethyl)phosphonate
• CAS NO: 1344682-04-7
• Molecular Weight: 298.319
• Mol File: 1344682-04-7.mol

Chemical Properties

• CAS DataBase Reference: diisopropyl (2-oxo-2-(o-tolyl)ethyl)phosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diisopropyl (2-oxo-2-(o-tolyl)ethyl)phosphonate(1344682-04-7)
• EPA Substance Registry System: diisopropyl (2-oxo-2-(o-tolyl)ethyl)phosphonate(1344682-04-7)

Safety Data

• Hazardous Substances Data: 1344682-04-7(Hazardous Substances Data)

Upstream product

• 1809-20-7 diisopropyl hydrogenphosphonate 
• 2373-76-4 2-methylcinnamic acid 
• 611-15-4 1-methyl-2-vinyl-benzene 

Relevant articles and documents

Acetonitrile-dependent oxyphosphorylation: A mild one-pot synthesis of β-ketophosphonates from alkenyl acids or alkenes

An efficient one-pot synthesis of β-ketophosphonates has been developed, via the reaction of α,β-alkenyl carboxylic acids or alkenes with H-phosphonates and air oxygen, catalyzed by CuSO4·5H2O in CH3CN. CH3CN plays a decisive role, probably by forming an active oxygen complex [(MeCN)nCuII-O-O·].

Β-carbonyl process for the preparation of phosphonic acid ester compound

The present invention discloses a preparation method for preparing beta-Ketophosphonates represented by a formula (III). The beta-Ketophosphonate is an oxygen-containing compound having a value, and is especially adopted as an important synthesis intermediate to be widely used in the famous HWE reaction to synthesize alpha,beta-unsaturated carbonyl compounds. According to the present invention, simple and commercialized olefin and hydrogen-phosphorite are adopted as raw materials to directly utilize oxygen as an oxidizing agent and an oxygen source under transition metal catalysis to prepare the beta-Ketophosphonates; the preparation method has advantages of cheap and easily available raw materials, mild reaction conditions, environmental-friendliness, high atom economy, wide substrate adaptability range, and no requirement of harsh reaction conditions such as equivalent organic metal reagent use, low temperature, no water, no oxygen and the like; and the method further has advantages of short preparation period, easy product purification, stable process conditions, convenient operation and safety, and is suitable for large-scale production.

Catalytic and direct oxyphosphorylation of alkenes with dioxygen and H-phosphonates leading to β-ketophosphonates

Direct access: The title reaction has been developed under mild reaction conditions (see scheme; DMSO=dimethyl sulfoxide). This reaction can be effectively scaled up and offers not only a green and attractive approach to β-ketophosphonates, but also a useful example of direct incorporation of an oxygen atom from dioxygen into organic frameworks. Copyright