1344686-00-5

Upstream product

• 434-64-0 perfluorotoluene 
• 586-42-5 3-acetylbenzoic acid 
• 31076-85-4 3-acetylbenzoyl chloride 
• 651-83-2 4-trifluoromethyl-2,3,5,6-tetrafluoroaniline 
• 1327280-85-2 3-acetyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)benzamide 

Relevant academic research and scientific papers

PALLADIUM(II)-CATALYZED SELECTIVE FLUORINATION OF BENZOIC ACIDS AND DERIVATIVES

A new method of ortho-fluorination for selectively fluorinating a benzoic acid or derivative compound where an aryl C—H bond is directly replaced by an aryl C—F bond is provided. The method comprises reacting a compound having the formula: wherein X is at

Palladium(II)-catalyzed selective monofluorination of benzoic acids using a practical auxiliary: A weak-coordination approach

Finally, a choice! A highly selective palladium(II)-catalyzed ortho-monofluorination reaction has been achieved for the first time through a weak coordination (see scheme; Ar=2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl) . Simple modification of this protocol allows for a choice between mono- and difluorination. The mono- and difluorinated benzoic acid derivatives are valuable in the pharmaceutical and agrochemical industries. Copyright