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134490-19-0

POLY(L-LACTIDE-CO-CAPROLACTONE-CO-GLYCO&, also known as PLGA-PCL, is a biodegradable block copolymer derived from the combination of L-lactide, caprolactone, and glycolide. It possesses unique properties such as biodegradability, biocompatibility, and tunable physical characteristics, making it a promising material for various applications in the medical and pharmaceutical industries.

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  • Poly(L-lactide-co-caprolactone-co-glycolide)(70:20:10)average Mn ~50,000 by GPC

    Cas No: 134490-19-0

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  • 134490-19-0 Structure

  • Basic information

    1. Product Name: POLY(L-LACTIDE-CO-CAPROLACTONE-CO-GLYCO&
    2. Synonyms: POLY(L-LACTIDE-CO-CAPROLACTONE-CO-GLYCO&
    3. CAS NO:134490-19-0
    4. Molecular Formula: C16H22O10
    5. Molecular Weight: 374.34
    6. EINECS: N/A
    7. Product Categories: Biodegradable Polymers;Lactide and Glycolide Polymers;Polymer Science;Biodegradable Polymers;Lactide and Glycolide Polymers;Materials Science;Polymer Science;Polymers
    8. Mol File: 134490-19-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: POLY(L-LACTIDE-CO-CAPROLACTONE-CO-GLYCO&(CAS DataBase Reference)
    10. NIST Chemistry Reference: POLY(L-LACTIDE-CO-CAPROLACTONE-CO-GLYCO&(134490-19-0)
    11. EPA Substance Registry System: POLY(L-LACTIDE-CO-CAPROLACTONE-CO-GLYCO&(134490-19-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 134490-19-0(Hazardous Substances Data)

134490-19-0 Usage

Uses

Used in Pharmaceutical Applications:
PLGA-PCL is used as a drug delivery system for controlled and sustained release of therapeutic agents. The copolymer's biodegradability and biocompatibility allow for safe and effective administration of drugs, reducing the frequency of dosing and improving patient compliance.
Used in Tissue Engineering and Regenerative Medicine:
PLGA-PCL is employed as a scaffold material in tissue engineering and regenerative medicine due to its biocompatibility and ability to support cell growth and differentiation. The copolymer can be tailored to degrade at a controlled rate, providing a temporary structure for new tissue formation.
Used in Nanoparticle-based Drug Delivery Systems:
PLGA-PCL is used as a core material for the development of nanoparticles, which can encapsulate and deliver drugs to specific target sites within the body. This application enhances the drug's bioavailability, reduces systemic side effects, and allows for targeted therapy.
Used in Vascular Grafts and Prostheses:
PLGA-PCL, in combination with electrospun nanofiber blends and phosphorylcholine groups, is used as a vascular graft and prosthesis material. The copolymer's mechanical properties and biocompatibility make it suitable for use in blood vessel repair and replacement.
Used in Anticancer Applications:
PLGA-PCL is used as a carrier for anticancer drugs, such as rapamycin, to enhance the drug's delivery and efficacy against cancer cells. The copolymer's controlled release properties allow for a sustained and targeted delivery of the therapeutic agent, improving treatment outcomes and reducing side effects.

Check Digit Verification of cas no

The CAS Registry Mumber 134490-19-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,4,9 and 0 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 134490-19:
(8*1)+(7*3)+(6*4)+(5*4)+(4*9)+(3*0)+(2*1)+(1*9)=120
120 % 10 = 0
So 134490-19-0 is a valid CAS Registry Number.

134490-19-0 Well-known Company Product Price

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  • Aldrich

  • (568562)  Poly(L-lactide-co-caprolactone-co-glycolide)  L-lactide 70 %, average Mn ~50,000 by GPC

  • 134490-19-0

  • 568562-1G

  • 1,905.93CNY

  • Detail

  • Aldrich

  • (568562)  Poly(L-lactide-co-caprolactone-co-glycolide)  L-lactide 70 %, average Mn ~50,000 by GPC

  • 134490-19-0

  • 568562-5G

  • 6,604.65CNY

  • Detail

134490-19-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Poly(L-lactide-co-caprolactone-co-glycolide)

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:134490-19-0 SDS

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