1344921-45-4Relevant articles and documents
Visible-Light-Driven Catalytic Deracemization of Secondary Alcohols
Hu, Xile,Zhang, Zhikun
supporting information, p. 22833 - 22838 (2021/09/09)
Deracemization of racemic chiral compounds is an attractive approach in asymmetric synthesis, but its development has been hindered by energetic and kinetic challenges. Here we describe a catalytic deracemization method for secondary benzylic alcohols which are important synthetic intermediates and end products for many industries. Driven by visible light only, this method is based on sequential photochemical dehydrogenation followed by enantioselective thermal hydrogenation. The combination of a heterogeneous dehydrogenation photocatalyst and a chiral molecular hydrogenation catalyst is essential to ensure two distinct pathways for the forward and reverse reactions. These reactions convert a large number of racemic aryl alkyl alcohols into their enantiomerically enriched forms in good yields and enantioselectivities.
Iron- and cobalt-catalyzed asymmetric hydrosilylation of ketones and enones with bis(oxazolinylphenyl)amine ligands
Inagaki, Tomohiko,Phong, Le Thanh,Furuta, Akihiro,Ito, Jun-Ichi,Nishiyama, Hisao
supporting information; experimental part, p. 3090 - 3096 (2010/08/05)
Chiral bis(oxazolinylphenyl)amines proved to be efficient auxiliary ligands for iron and cobalt catalysts with high activity for asymmetric hydrosilylation of ketones and asymmetric conjugate hydrosilylation of enones.