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13450-72-1

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13450-72-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 13450-72-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,4,5 and 0 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 13450-72:
(7*1)+(6*3)+(5*4)+(4*5)+(3*0)+(2*7)+(1*2)=81
81 % 10 = 1
So 13450-72-1 is a valid CAS Registry Number.
InChI:InChI=1/C18H21N3O/c1-20(2)12-7-13-21-16-10-5-3-8-14(16)18(22)19-15-9-4-6-11-17(15)21/h3-6,8-11H,7,12-13H2,1-2H3,(H,19,22)

13450-72-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 11-[3-(dimethylamino)propyl]-5H-benzo[b][1,4]benzodiazepin-6-one

1.2 Other means of identification

Product number -
Other names 5-(3-dimethylamino-propyl)-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:13450-72-1 SDS

13450-72-1Downstream Products

13450-72-1Relevant articles and documents

Tricyclic compounds as selective antimuscarinics. 1. Structural requirements for selectivity toward the muscarinic acetylcholine receptor in a series of pirenzepine and imipramine analogues

Eberlein,Trummlitz,Engel,Schmidt,Pelzer,Mayer

, p. 1378 - 1382 (1987)

The M1-selective antiulcer drug pirenzepine (1) is a tricyclic compound with close resemblance to tricyclic psychotropic agents such as imipramine (2). Despite this fact, pirenzepine is devoid of any psychotropic effects, exhibiting measurable antagonistic effects in biochemical assays and receptor binding studies only toward the muscarinic receptor system. To understand how different groups in these tricyclic molecules affect binding affinities, a set of nine compounds structurally related to pirenzepine (1) and imipramine (2) has been selected for analysis, comprising three different tricycles and three different side chains. The compounds were tested for their affinity to the imipramine and muscarinic receptors in homogenized rat cortex tissue. The result of these studies suggests that it is the nature and placement of accessory groups that determine the differences in receptor recognition and the binding process. In the case of pirenzepine (1), preferential binding toward the muscarinic receptor is brought about by the endocyclic amide group, by the positioning of the protonated N atom of the side chain, and to a minor extent by the exocyclic amide group. From these findings a putative model for the explanation of selective binding of pirenzepine (1) to the muscarinic receptor has been derived.

The N-Aryl aminocarbonyl ortho-substituent effect in Cu-catalyzed aryl amination and its application in the synthesis of 5-substituted 11-Oxo-dibenzodiazepines

Diao, Xiaoqiong,Xu, Lanting,Zhu, Wei,Jiang, Yongwen,Wang, Haoyang,Guo, Yinlong,Ma, Dawei

supporting information; experimental part, p. 6422 - 6425 (2012/02/03)

Double amination of ortho-substituted aryl bromides proceeded under mild conditions to afford 5-substituted 11-oxo-dibenzodiazepines, which revealed that there is a strong ortho-substituent effect caused by N-aryl aminocarbonyl groups during copper-cataly

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