1345097-54-2Relevant academic research and scientific papers
Biomimetic synthetic studies on lactonamycin: An expedient synthesis of dihydroxy-isoindolinone-carboxylates
Jacques, Sylvain A.,Patel, Bhavesh H.,Barrett, Anthony G.M.
, p. 6072 - 6075 (2011)
The synthesis of dihydroxy-isoindolinone-carboxylates from a dioxinone keto-ester and N-protected sarcosine without the use of phenolic protection is described. Base-induced aromatization of the dioxinone diketo-ester followed by lactamization furnished the desired dihydroxy-isoindolinone moiety, which could be used as an EF-ring precursor toward the synthesis of lactonamycin.
