134511-41-4Relevant academic research and scientific papers
Process and intermediate for the preparation of 2-hydroxy-3-sulfido-3-phenyl propanoic acids
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, (2008/06/13)
STR1 This invention relates to intermediate compounds of formula (VI), wherein: R1 is (L)a --(CH2)b --(T)c --B; a is 0 or 1; b is 3 to 14; c is 0 or 1; L and T are independently sulfur, oxygen, CH=CH, C C, or CH2 ; B is H, C1-4 alkyl, ethynyl, trifluoromethyl, isopropenyl, furanyl, thienyl, cyclohexyl or phenyl unsubstituted or monosubstituted by Br, Cl, CF3, C1-4 alkoxy, C1-4 alkyl, methylthio or trifluoromethylthio; R2 and A are independently selected from H, CF3, C1-4 alkyl, C1-4 alkoxy, F, Cl, Br, I, OH, NO2 or NH2 ; or, when R1 and A are H, R2 is (L)a --(CH2)b --(T)c --B wherein a, b, c, L, T and B are as defined above; and M is H, Li, Na, K, NH4 or an organic ammonium cation, and their use in a process for preparing leukotriene antagonists.
LEUKOTRIENE ANTAGONISTS
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, (2008/06/13)
This invention relates to alkanoic acid compounds having phenyl and heteroarylthio substituents which are useful as leukotriene antagonists, processes for the preparation thereof, and pharmaceutical compositions containing such compounds.This invention also relates to methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.
Process for preparation of epoxy esters and intermediates prepared thereby
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, (2008/06/13)
This invention relates to a process for preparing epoxy esters, and intermediates prepared by this process, in particular, to a process which produces non-racemic epoxy esters which are of use as intermediates in the preparation of pharmaceutical compounds.
