1345157-39-2Relevant academic research and scientific papers
Highly enantioselective organocatalytic cascade reaction for the synthesis of piperidines and oxazolidines
?íhalová, Sylva,Valero, Guillem,Schimer, Ji?í,Humpl, Marek,Dra?ínsky, Martin,Moyano, Albert,Rios, Ramon,Vesely, Jan
experimental part, p. 8942 - 8950 (2011/12/01)
The synthesis of piperidines and piperidines derivatives in enantiopure fashion has been a challenging goal for organic chemists. In this report we developed a nice cascade reaction for piperidine derivatives based in an amidomalonate Michael addition to enals followed by an intramolecular hemiaminal formation with good yields and enantioselectivities. Moreover we studied the 'in situ' intramolecular cyclization of this hemiaminals with alcohols forming fused piperidine-oxazolidines.
Highly enantioselective organocatalytic synthesis of piperidines. Formal synthesis of (-)-Paroxetine
Valero, Guillem,Schimer, Jiri,Cisarova, Ivana,Vesely, Jan,Moyano, Albert,Rios, Ramon
scheme or table, p. 1943 - 1946 (2009/09/28)
A highly enantioselective organocatalytic synthesis of piperidines is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the corresponding adducts with high yields and enantioselectivities. Moreover, this
