1345157-50-7

Basic information

• Product Name: (3S,4R,6R)-ethyl 1-benzyl-4-(2-bromophenyl)-6-hydroxy-2-oxopiperidine-3-carboxylate
• Synonyms: (3S,4R,6R)-ethyl 1-benzyl-4-(2-bromophenyl)-6-hydroxy-2-oxopiperidine-3-carboxylate
• CAS NO: 1345157-50-7
• Molecular Weight: 432.314
• Mol File: 1345157-50-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3S,4R,6R)-ethyl 1-benzyl-4-(2-bromophenyl)-6-hydroxy-2-oxopiperidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,4R,6R)-ethyl 1-benzyl-4-(2-bromophenyl)-6-hydroxy-2-oxopiperidine-3-carboxylate(1345157-50-7)
• EPA Substance Registry System: (3S,4R,6R)-ethyl 1-benzyl-4-(2-bromophenyl)-6-hydroxy-2-oxopiperidine-3-carboxylate(1345157-50-7)

Safety Data

• Hazardous Substances Data: 1345157-50-7(Hazardous Substances Data)

Upstream product

• 138555-58-5 2-bromocinnamaldehyde 
• 29689-63-2 ethyl (N-benzylcarbamoyl)acetate 

Relevant articles and documents

Highly enantioselective organocatalytic cascade reaction for the synthesis of piperidines and oxazolidines

The synthesis of piperidines and piperidines derivatives in enantiopure fashion has been a challenging goal for organic chemists. In this report we developed a nice cascade reaction for piperidine derivatives based in an amidomalonate Michael addition to enals followed by an intramolecular hemiaminal formation with good yields and enantioselectivities. Moreover we studied the 'in situ' intramolecular cyclization of this hemiaminals with alcohols forming fused piperidine-oxazolidines.