134516-99-7

Basic information

• Product Name: U 90042
• Synonyms: U 90042;11-Chloro-5-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-2,3-dihydrodiimidazo[1,5-a:1',2'-c]quinazoline
• CAS NO: 134516-99-7
• Molecular Formula: C17H13ClN6O
• Molecular Weight: 352.784
• Mol File: 134516-99-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Store at RT
• CAS DataBase Reference: U 90042(CAS DataBase Reference)
• NIST Chemistry Reference: U 90042(134516-99-7)
• EPA Substance Registry System: U 90042(134516-99-7)

Safety Data

• Hazardous Substances Data: 134516-99-7(Hazardous Substances Data)

Usage

Uses

U 90042 is a sedative and hypnotic compound that interacts differentially with the GABAA receptor subtypes.

Biological Activity

GABA A receptor ligand that binds with comparable affinities to three receptor subtypes: α 1 β 2 γ 2 , α 3 β 2 γ 2 and α 6 β 2 γ 2 (K i values are 7.8, 9.5 and 11.0 nM respectively). Potentiates GABA-induced chloride currents in α 6 β 2 γ 2 receptors. Sedative/hypnotic compound.

Upstream product

• 134517-26-3 5,9-dichloro-2,3-dihydroimidazo[1,2-c]quinazoline 
• 106447-64-7 5-Cyclopropyl-3-isocyanomethyl-1,2,4-oxadiazole 

Relevant articles and documents

Heterocyclic compounds and their preparation and use

New imidazoquinazoline compounds having the general formula STR1 wherein A together with the α-marked carbon atom and the β-marked nitrogen atom is one of the groups STR2 wherein R4, R5, R6 and R7 independently are hydrogen, halogen C1-6 -alkyl, aryl or aralkyl R1 is STR3 cyano or CO2 R8, wherein R8 is hydrogen, C1-6 -alkyl or C3-7 -cycloalkyl, trifluoromethyl or C1-6 -alkoxymethyl, R2 and R3 independently are hydrogen, halogen, CN, C1-6 -alkyl, C2-6 -alkenyl, C2-6 -alkynyl, trifluoromethyl, C1-6 -alkoxy, dialkylaminoalkoxy, aralkoxy, aryloxy which may be substituted with halogen or alkoxy, a cyclic amino group, or NR9 R10, wherein R9 and R10 independently are hydrogen or C1-6 -alkyl. The compounds are useful in psychopharmaceutical preparations as anticonvusants, anxiolytics, hypnotics, antipsychotics, antiemetics, or in improving the cognitive function of the brain of mammals.