134523-61-8Relevant articles and documents
Stereoselective synthesis of C24-hydroxylated vitamin D3 analogs: A practical and expeditius route to calcipotriol
Rumbo, Antonio,Perez-Garcia, Xenxo,Mourino, Antonio
scheme or table, p. 68 - 70 (2011/11/14)
The synthesis of the clinically important drug calcipotriol (2, MC903) is described as an example of a new and efficient approach to C24-hydroxylated analogs and metabolites of vitamin D3 (1). The key step of the process is the generation of the C24 stereocenter by DAIB [(-)-3-exo-(dimethylamino)isoborneol]-catalyzed addition of the alkenylzinc derivative of alkyne 3 to cyclopropylcarboxaldehyde.
ISOMERISATION OF PHARMACEUTICAL INTERMEDIATES
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Page/Page column 20, (2008/06/13)
The present invention relates to an isomerisation method of vitamin D analogues, such as compounds useful for the synthesis of calcipotriol, and to and to the use of a flow- through photoreactor or continuous flow photoreactor reactor for making said vitamin D analogues. The present invention relates further to the use of intermediates produced with said method for making calcipotriol or calcipotriol monohydrate, or pharmaceutical formulations thereof.
STEREOSELECTIVE SYNTHESIS OF VITAMIN D ANALOGUES
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Page/Page column 29-30, (2008/06/13)
The present invention relates to intermediates useful for the synthesis of calcipotriol or calcipotriol monohydrate, to methods of producing said intermediates, and to methods of stereoselectively reducing said intermediates.