1345265-75-9

Basic information

• Product Name: 3,5-bis(trifluoromethyl)anilino-2-[(4S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl]-3,5-bis(trifluoromethyl)anilinomethanethione
• CAS NO: 1345265-75-9
• Molecular Weight: 611.454
• Mol File: 1345265-75-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,5-bis(trifluoromethyl)anilino-2-[(4S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl]-3,5-bis(trifluoromethyl)anilinomethanethione(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-bis(trifluoromethyl)anilino-2-[(4S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl]-3,5-bis(trifluoromethyl)anilinomethanethione(1345265-75-9)
• EPA Substance Registry System: 3,5-bis(trifluoromethyl)anilino-2-[(4S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl]-3,5-bis(trifluoromethyl)anilinomethanethione(1345265-75-9)

Safety Data

• Hazardous Substances Data: 1345265-75-9(Hazardous Substances Data)

Upstream product

• 1345265-88-4 2-[(4S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl]-3,5-bis(trifluoromethyl)aniline 
• 23165-29-9 3,5-bistrifluoromethylphenylisothiocyanate 
• 2026-48-4 (S)-valinol 
• 98012-88-5 6-amino-2,4-bis(trifluoromethyl)benzonitrile 
• 328-75-6 1-nitro-3,5-bis(trifluoromethyl)benzene 
• 328-74-5 3,5-Bis-(trifluoromethyl)aniline 

Relevant articles and documents

Cooperative thiourea-Bronsted acid organocatalysis: Enantioselective cyanosilylation of aldehydes with TMSCN

We report a new thiourea - Bronsted acid cooperative catalytic system for the enantioselective cyanosilylation of aldehydes with yields up to 90% and enantioselectivities up to 88%. The addition of an achiral acid was found to be crucial for high asymmetric induction. Mechanistic investigations using a combination of NMR, ESI-MS, and density functional theory computations (including solvent corrections) at the M06/6-31G(d,p) level of theory suggest that the key catalytic species results from the cooperative interaction of bifunctional thioureas and an achiral acid that form well-defined chiral hydrogen-bonding environments.