134541-91-6

Usage

Structure

A carbonyl chloride derivative of 1-phenyl-1H-1,2,3-triazole-4-carboxylic acid, with a triazole ring and a phenyl group attached to it.

Reactivity

Highly reactive acylating agent

Uses

Commonly used as a key building block in the synthesis of various pharmaceuticals and agrochemicals, widely utilized in the preparation of heterocyclic compounds, and as an intermediate in the synthesis of antifungal, antifolate, and anticancer agents.

Importance

Essential reagent in the preparation of diverse chemical libraries for drug discovery and development, used in research in the fields of medicinal chemistry and chemical biology.

Upstream product

• 4915-97-3 1-phenyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester 
• 61456-87-9 1-phenyl-1H-1,2,3-triazole-4-carbonitrile 
• 62-53-3 aniline 
• 622-37-7 Phenyl azide 

Downstream Products

• 134541-90-5 N-(1-Hydroxy-2-methylpropan-2-yl)-1-phenyl-1,2,3-triazole-4-carboxamide 
• 134541-79-0 N,N-Diethyl-1-phenyl-1,2,3-triazole-4-carboxamide 
• 134541-88-1 Dimethyl 2-(4,5-dihydro-4,4-dimethoxyloxazol-2-yl)-1-anilinocyclobutene-3,4-dicarboxylate 
• 134541-84-7 N,N-Diethyl-N'-phenyl-4-chlorobenzylidenemalonamide 
• 134541-83-6 2-Phenylamino-1-oxa-spiro[3.5]non-2-ene-3-carboxylic acid diethylamide 
• 134541-86-9 2-Cyclohexylidene-2-(4,5-dihydro-4,4-dimethyloxazol-2-yl)-N-phenylacetamide 
• 134541-85-8 1-(4,5-Dihydro-4,4-dimethyloxazol-2-yl)-2-(N-methoxycarbonylanilino)ethyne 
• 134541-82-5 N,N-Diethyl-N'-phenylcyclohexylidenemalonamide 
• 134541-81-4 N,N-Diethyl-3-(N-methoxycarbonylanilino)propynamide 
• 134541-80-3 4-(4,5-Dihydro-4,4-dimethyloxazol-2-yl)-1-phenyl-1,2,3-triazole 

Relevant academic research and scientific papers

NOVEL OXABOROLE ANALOGS AND USES THEREOF

This application describes compounds, compositions, and methods which are useful in treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite.

Discovery of a novel 6,7-disubstituted-4-(2-fluorophenoxy)quinolines bearing 1,2,3-triazole-4-carboxamide moiety as potent c-Met kinase inhibitors

A series of 6,7-disubstituted-4-(2-fluorophenoxy)quinoline derivatives possessing 1,2,3-triazole-4-carboxamide moiety were designed, synthesized and evaluated for their in vitro cytotoxic activities against four typical cancer cell lines (A549, H460, HT-29, and MKN-45). Most compounds showed moderate-to-excellent antiproliferative activity. Compounds 32, 36, 37, 45, 51, and 52 were further examined for their inhibitory activity against c-Met kinase. The promising compound 37, with a c-Met IC50 value of 2.27 nM, was identified as a multitargeted receptor tyrosine kinase inhibitor. The analysis of their structure-activity relationships indicated that compounds with EWGs, especially chloro group, at 2-position on the phenyl ring (moiety B) have potent antitumor activity.

Triazole containing novobiocin and biphenyl amides as Hsp90 C-terminal inhibitors

Hsp90 C-terminal inhibitors are advantageous for the development of new cancer chemotherapeutics due to their ability to segregate client protein degradation from induction of the prosurvival heat shock response, which is a major detriment associated with

Synthesis of aminoquinolones from triazoles via carboxamido-ketenimine and amidinoketene intermediates

1-Aryl-1H-1,2,3-triazole-4-carboxamides 7d-f have been synthesized and converted to 2-dimethylamino-4-quinolones 12d-f by flash vacuum thermolysis (FVT). The reaction takes place via carboxamidoketenimine 9 and amidinoketene intermediates 10. The former are observed by FTIR spectroscopy at 77 K or in Ar matrices at 12 K.