1345510-79-3Relevant academic research and scientific papers
Synthesis and in vitro evaluation of novel indole-based sigma receptors ligands
Yarim, Mine,Koksal, Meric,Schepmann, Dirk,Wuensch, Bernard
, p. 869 - 875 (2011)
To investigate the molecular features involved in sigma (σ) receptors binding, a series of compounds based on indole scaffolds were synthesized and their chemical structures were confirmed by 1H-NMR, IR, and elemental analysis. Their affinity t
Design, synthesis, and biological evaluation of indole-based 1,4-disubstituted piperazines as cytotoxic agents
Akkoc, Meric Koeksal,Yueksel, Mine Yarim,Durmaz, Irem,Atalay, Renguel Ecetin
experimental part, p. 515 - 525 (2012/09/22)
A series of 3-[(4-substitutedpiperazin-1-yl)methyl]-1H -indole derivatives were synthesized, and their structures were confirmed by spectral analysis. All the compounds were tested for their cytotoxic activity in vitro against 3 human tumor cell lines: human liver (HUH7), breast (MCF7), and colon (HCT116). Among the designed derivatives, most of the compounds showed significant cytotoxicity against liver and colon cancer cell lines with lower IC50 concentrations than the standard drug 5-fluorouracil. Compound 3s, with 3,4-dichlorophenyl substituent on the piperazine ring, was the most active in suppressing the growth of all screened cancer cells. TUeBITAK.
