1345561-85-4

Upstream product

• 3587-60-8 Benzyloxymethyl chloride 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 163759-50-0 5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(2-methoxyethyl)-5-methyluridine 
• 1345564-44-4 C₅₀H₅₆N₂O₉Si 
• 1345676-10-9 C₅₈H₆₄N₂O₁₀Si 

Downstream Products

• 1345719-96-1 C₄₈H₆₅N₂O₁₄PSi 
• 1345719-94-9 C₄₈H₆₅N₂O₁₄PSi 
• 1345561-88-7 C₃₇H₄₄N₂O₈Si 
• 1345676-11-0 C₄₄H₆₂N₂O₁₃P₂Si 

Relevant academic research and scientific papers

Modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom

The present invention provides modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom. More particularly, the present invention provides modified nucleosides and analogs thereof that are useful for incorporation at the terminus of an oligomeric compound. Such oligomeric compounds can also be included in a double stranded composition. In some embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.

5' MODIFIED NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM

The present invention provides 5′ modified nucleosides and oligomeric compounds prepared therefrom. More particularly, the present invention provides modified nucleosides having at least one 5′-substituent and an optional 2′ substituent, oligomeric compounds comprising at least one of these modified nucleosides and methods of using the oligomeric compounds. In some embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.

MODIFIED 5' DIPHOSPHATE NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM

Provided herein are modified 5′ diphosphate nucleosides and oligomeric compounds prepared therefrom. More particularly, modified 5′ diphosphate nucleosides are provided that can be further modified at the 2′ and 5′ positions. In some embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The oligomeric compounds are also expected to be useful as primers and probes in diagnostic applications.